Brand Name: Caflam

Generic Name: Diclofenac Potassium

Active Ingredient(s): Diclofenac Potassium (50 mg)

For the General Public:

Uses:

Caflam 50 mg is used for:

• Relieving pain, inflammation, and swelling associated with conditions such as arthritis, menstrual pain, and musculoskeletal injuries.
• Managing acute migraine attacks.

How It Works:

Caflam is a nonsteroidal anti-inflammatory drug (NSAID) that works by inhibiting the production of prostaglandins, substances in the body that cause pain and inflammation.

Dosage and Administration:

• Dosage: One tablet 2-3 times a day, or as directed by your healthcare provider.
• Instructions: Take with food or after meals to minimize stomach upset.

Possible Side Effects:

• Common Side Effects: Stomach pain, nausea, heartburn, dizziness, or headache.
• Serious Side Effects: Severe abdominal pain, black or bloody stools, swelling, or difficulty breathing. Seek medical attention immediately if these occur.

Important Information:

• Usage Instructions:
  • Do not exceed the recommended dose.
  • Take as prescribed, even if symptoms improve.
• General Information:
  • Avoid alcohol, as it may increase the risk of stomach bleeding.
  • Keep out of reach of children.

Precautions:

• Inform your doctor if you have a history of ulcers, gastrointestinal bleeding, heart disease, or kidney/liver issues.
• Use cautiously during pregnancy, especially in the third trimester, or while breastfeeding.

Drug Interactions:

• With Other Medications:
  • Avoid combining with other NSAIDs, blood thinners, or corticosteroids.
• With Food:
  • Taking the tablet with food or milk can reduce the risk of stomach irritation.

Regulatory Approval & Manufacturer:

• Approved by [Regulatory Authority] and manufactured by [Manufacturer].

Antidotes (If Overdose or Misuse):

• Symptoms of overdose include severe dizziness, nausea, vomiting, or difficulty breathing. Seek immediate medical attention.

For Pharmacists:

Medicine Name: Caflam

Brand: Caflam
Active Ingredient(s): Diclofenac Potassium (50 mg)

Indications:

• Management of acute and chronic pain.
• Treatment of inflammatory conditions such as osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis.
• Relief of dysmenorrhea (menstrual pain).

Pharmacodynamics:

• Mechanism of Action:
  • Diclofenac inhibits cyclooxygenase (COX-1 and COX-2) enzymes, reducing the synthesis of prostaglandins, thereby alleviating pain and inflammation.
• Pharmacological Effects:
  • Reduces inflammation and swelling.
  • Relieves pain and improves joint mobility.
• Receptor Binding:
  • Diclofenac has a high affinity for COX enzymes, particularly COX-2, which plays a key role in inflammation.

Pharmacokinetics:

• Absorption: Rapidly absorbed; peak plasma levels reached within 1–2 hours.
• Distribution: Extensively bound to plasma proteins (~99%).
• Metabolism: Metabolized in the liver via CYP2C9.
• Elimination: Excreted primarily in urine and bile.
• Half-Life: 1–2 hours.

Dosage and Administration:

• Adults: 50 mg tablet 2-3 times daily, depending on the severity of the condition.
• Special Populations:
  • Use cautiously in elderly patients or those with hepatic or renal impairment.

Contraindications:

• Hypersensitivity to diclofenac or other NSAIDs.
• History of gastrointestinal bleeding or peptic ulcers.
• Severe heart, kidney, or liver failure.

Warnings and Precautions:

• Long-term use increases the risk of cardiovascular events, such as heart attack or stroke.
• Monitor for signs of gastrointestinal bleeding, especially in high-risk patients.
• Use with caution in patients with hypertension or fluid retention.

Drug Interactions:

• With Other Medications:
  • Increases the risk of bleeding with anticoagulants (e.g., warfarin).
  • May reduce the effectiveness of antihypertensive drugs.
• Drug-Food Interactions:
  • Food may delay absorption but does not affect the overall bioavailability of diclofenac.

Adverse Reactions:

• Common: Dyspepsia, abdominal pain, nausea, headache, or rash.
• Serious: Gastrointestinal perforation, liver enzyme elevations, or renal impairment.

Therapeutic Effects:

• Effectively reduces pain and inflammation.
• Improves quality of life in patients with chronic inflammatory conditions.

Storage:

• Store at 20–25°C, away from direct sunlight and moisture.

Packaging:

• Supplied in blister packs containing 2×10 tablets (50 mg each).

Clinical Considerations:

• Pregnancy Category: C (Avoid during the third trimester).
• Lactation: Use with caution; consult a healthcare provider.
• Pediatric Use: Safety and efficacy not established.
• Geriatric Use: Monitor for potential renal, hepatic, or cardiovascular complications.

Conclusion:

Caflam 50 mg is an effective NSAID for managing pain and inflammation associated with various conditions. Proper dosing and monitoring are essential to minimize potential risks and side effects. Always consult a healthcare provider for individualized advice.