Generic Name: Piroxicam Beta-Cyclodextrin

Active Ingredient(s): Piroxicam Beta-Cyclodextrin (20 mg)

For the General Public:

Uses:

Brexin is used for:

• Relief of pain and inflammation in conditions like osteoarthritis, rheumatoid arthritis, and musculoskeletal disorders.
• Short-term management of acute pain, such as dental pain or post-surgical pain.

How It Works:

Brexin contains piroxicam, an NSAID, combined with beta-cyclodextrin, which enhances its solubility and absorption. It works by inhibiting the activity of cyclooxygenase (COX) enzymes, reducing the production of prostaglandins responsible for pain and inflammation.

Dosage:

• Take as directed by your healthcare provider, typically one tablet daily with a meal.

Possible Side Effects:

• Common Side Effects: Nausea, indigestion, headache, dizziness, or abdominal discomfort.
• Serious Side Effects: Stomach ulcers, gastrointestinal bleeding, kidney dysfunction, or severe allergic reactions. Seek medical attention if these occur.

Important Information:

• Dosage Instruction: Take one tablet daily, preferably after a meal.
• Usage Instruction:
  • Avoid alcohol, which may increase the risk of stomach bleeding.
  • Follow the prescribed dose strictly and avoid long-term use unless advised by a doctor.
• General Information:
  • Not suitable for individuals with a history of gastrointestinal ulcers or bleeding.
  • Consult a healthcare provider if pregnant, breastfeeding, or planning pregnancy.
  • Keep out of reach of children.

Drug Interactions:

• With Other Medications:
  • Avoid combining with other NSAIDs or blood-thinning medications (e.g., aspirin, warfarin).
• With Food:
  • Taking with food reduces stomach irritation without affecting drug absorption.

Regulatory Approval & Manufacturer:

• Approved by [Regulatory Authority] and manufactured by [Manufacturer].

Antidotes (If Overdose or Misuse):

• Administer activated charcoal if overdose occurs within an hour of ingestion. Symptomatic treatment may be required for complications like gastrointestinal bleeding or kidney impairment.

For Pharmacists:

Medicine Name: Brexin

Brand: Brexin
Active Ingredient(s): Piroxicam Beta-Cyclodextrin

Indications:

• Management of pain and inflammation in conditions like osteoarthritis, rheumatoid arthritis, and musculoskeletal disorders.
• Short-term treatment of acute pain.

Pharmacodynamics:

• Mechanism of Action:
  Piroxicam inhibits cyclooxygenase (COX-1 and COX-2) enzymes, reducing prostaglandin production to alleviate pain and inflammation.
• Pharmacological Effects:
  • Reduces swelling, stiffness, and pain in inflammatory conditions.
  • Improves joint mobility.
• Receptor Binding:
  Piroxicam binds to COX enzymes in inflammatory sites, exerting anti-inflammatory and analgesic effects.

Pharmacokinetics:

• Absorption: Enhanced absorption due to beta-cyclodextrin complex, leading to faster onset of action.
• Distribution: High plasma protein binding (~99%).
• Metabolism: Metabolized in the liver by hydroxylation and conjugation pathways.
• Elimination: Excreted via urine and feces.
• Half-Life: Approximately 30–60 hours.

Dosage and Administration:

• Adults: One tablet (20 mg) daily, preferably with food.
• Duration: Use the lowest effective dose for the shortest duration necessary.

Special Populations:

• Renal Impairment: Use with caution; dose adjustment may be necessary.
• Hepatic Impairment: Monitor liver function; adjust dosage as needed.

Contraindications:

• Hypersensitivity to piroxicam, beta-cyclodextrin, or NSAIDs.
• History of gastrointestinal ulcers, bleeding, or perforation.
• Severe kidney or liver impairment.

Warnings and Precautions:

• Increased risk of cardiovascular events (e.g., heart attack, stroke) with prolonged use.
• May cause gastrointestinal bleeding or ulceration.
• Avoid in patients with a history of NSAID-induced asthma or allergic reactions.

Drug-Drug Interactions:

• Anticoagulants (e.g., warfarin): Increased risk of bleeding.
• Diuretics: Reduced efficacy and potential renal impairment.
• Corticosteroids: Increased risk of gastrointestinal side effects.

Drug-Food Interactions:

• Food minimizes gastrointestinal side effects but does not alter the drug’s efficacy or absorption.

Adverse Reactions:

• Common: Dyspepsia, abdominal pain, headache, or dizziness.
• Serious: Gastrointestinal bleeding, kidney dysfunction, or hypersensitivity reactions.

Therapeutic Effects:

• Effectively reduces pain and inflammation, improving the quality of life for patients with inflammatory conditions.

Storage:

• Store at 20–25°C, away from moisture, heat, and light.

Packaging:

• Available in blister packs of 20 tablets.

Clinical Considerations:

• Pregnancy Category: C (Use only if benefits outweigh risks).
• Lactation: Caution advised; unknown if excreted in breast milk.
• Pediatric Use: Safety and efficacy not established.
• Geriatric Use: Increased sensitivity to adverse effects; use the lowest effective dose.

Conclusion:

Brexin 20 mg is an effective NSAID for managing pain and inflammation in arthritis and other conditions. Its beta-cyclodextrin complex improves solubility and onset of action. Proper administration, adherence to dosage, and monitoring of side effects ensure optimal therapeutic outcomes. Always consult a healthcare professional for personalized advice.