Bludol Tab 200 mg 10×10’s-Potential Overview:

Brand Name: Bludol
Generic Name: Ibuprofen
Active Ingredient(s): Ibuprofen (200 mg)

For the General Public:

Uses:
Bludol tablets are commonly used for:

• Relief of mild to moderate pain (e.g., headache, toothache, menstrual cramps).
• Reduction of fever.
• Alleviating inflammation associated with arthritis or other musculoskeletal conditions.

How It Works:
Ibuprofen belongs to the non-steroidal anti-inflammatory drug (NSAID) class. It reduces pain, inflammation, and fever by inhibiting the cyclooxygenase (COX) enzymes, which decreases the production of prostaglandins in the body.

Dosage:

• Adults: 1–2 tablets every 4–6 hours as needed. Do not exceed 6 tablets in 24 hours unless directed by a doctor.
• Children: Use pediatric dosage as advised by a doctor.

Possible Side Effects:

• Common Side Effects: Nausea, heartburn, dizziness, and stomach upset.
• Serious Side Effects: Severe allergic reactions (rash, swelling, breathing difficulty), gastrointestinal bleeding, or kidney problems.

Important Information:

• Dosage Instruction: Take with water and food to minimize stomach upset.
• Usage Instruction: Do not crush or chew the tablet. Swallow whole.
• General Information:
  • Avoid use if allergic to ibuprofen, aspirin, or other NSAIDs.
  • Consult a doctor if you are pregnant, breastfeeding, or have a history of heart disease or stomach ulcers.
  • Do not combine with alcohol as it increases the risk of stomach irritation.

Drug Interactions:

• With Other Medications:
  • Avoid combining with anticoagulants, aspirin, or other NSAIDs.
  • May reduce the effectiveness of antihypertensive drugs.
• With Food:
  • Food may delay absorption but reduces the risk of gastrointestinal side effects.

Regulatory Approval & Manufacturer:
Approved by [Regulatory Authority], manufactured by [Manufacturer].

Antidotes (If Overdose or Misuse):
In case of overdose, symptoms may include severe stomach pain, vomiting, drowsiness, or difficulty breathing. Immediate medical intervention is required. Activated charcoal or supportive measures may be used.

For Pharmacists:

Medicine Name: Bludol
Brand: Bludol
Active Ingredient(s): Ibuprofen

Indications:

• Management of pain, fever, and inflammation in conditions like osteoarthritis, dysmenorrhea, and post-operative pain.

Pharmacodynamics:

• Mechanism of Action:
  Ibuprofen inhibits COX-1 and COX-2 enzymes, reducing prostaglandin synthesis and thereby alleviating inflammation, pain, and fever.
• Pharmacological Effects:
  • Anti-inflammatory: Reduces swelling and redness.
  • Analgesic: Relieves pain by acting on peripheral pain pathways.
  • Antipyretic: Lowers fever by acting on the hypothalamus.
• Receptor Binding:
  Ibuprofen does not bind to specific receptors but exerts its effects through inhibition of the COX enzymes.

Pharmacokinetics:

• Absorption:
  Rapidly absorbed after oral administration; peak plasma levels reached within 1–2 hours.
• Distribution:
  Extensively bound to plasma proteins (~99%).
• Metabolism:
  Metabolized in the liver through hydroxylation and carboxylation pathways.
• Elimination:
  Excreted primarily via urine as metabolites.
• Half-Life: 1.8–2 hours.
• Effect of Food:
  Food may delay absorption slightly but does not affect the overall bioavailability.

Dosage and Administration:

• Adults: 200–400 mg every 4–6 hours as needed. Do not exceed 1200 mg/day without medical advice.
• Pediatric: Dosage based on weight; consult a pediatrician.
• Special Populations:
  • Adjust dose in patients with renal or hepatic impairment.

Contraindications:

• Known hypersensitivity to ibuprofen or other NSAIDs.
• Patients with active gastrointestinal bleeding or ulceration.
• Severe heart failure, kidney, or liver disease.

Warnings and Precautions:

• Use cautiously in patients with a history of gastrointestinal conditions, cardiovascular disease, or renal impairment.
• Prolonged use may increase the risk of cardiovascular events or gastrointestinal bleeding.

Drug-Drug Interactions:

• Increased bleeding risk with anticoagulants.
• May decrease the efficacy of ACE inhibitors or diuretics.
• Avoid combining with corticosteroids or other NSAIDs.

Drug-Food Interactions:

• Food can delay drug absorption but reduces stomach irritation.

Adverse Reactions:

• Common: Nausea, dyspepsia, and dizziness.
• Serious: Gastrointestinal bleeding, anaphylaxis, renal dysfunction.

Therapeutic Effects:

• Provides effective relief from pain and inflammation.

Storage:
Store at 15–30°C, away from moisture and sunlight.

Packaging:
Blister packs containing 10 tablets per strip, with 10 strips in the box (10×10’s).

Clinical Considerations:

• Pregnancy Category: C (Avoid use during the third trimester).
• Lactation: Caution advised; consult a doctor.
• Geriatric Use: Use with caution; monitor for gastrointestinal or renal side effects.
• Pediatric Use: Consult specific dosage guidelines for children.

Conclusion:

Bludol 200 mg tablets are effective for managing pain, fever, and inflammation. While generally safe when used as directed, caution should be taken to avoid overuse and monitor for adverse effects, especially in at-risk populations. Always consult with a healthcare provider for appropriate use.