Blokium Tab 50 mg 30’s-Potential Overview:

Brand Name: Blokium
Generic Name: Atenolol
Active Ingredient(s): Atenolol (50 mg)

For the General Public:

Uses:
Blokium is prescribed for:

• High blood pressure (hypertension).
• Angina (chest pain).
• Reducing the risk of heart attacks by decreasing the workload on the heart.

How It Works:
Atenolol is a beta-blocker that works by slowing the heart rate and reducing the force of contraction, leading to lowered blood pressure and decreased strain on the heart.

Dosage:

• Typical dose: 50 mg once daily.
• Follow your doctor’s instructions or the medication label.

Possible Side Effects:

• Common Side Effects: Fatigue, dizziness, slow heart rate, and cold extremities.
• Serious Side Effects: Severe low blood pressure, irregular heartbeat, or difficulty breathing.

Important Information:

• Dosage Instruction: Take exactly as prescribed. Do not double the dose if a dose is missed.
• Usage Instruction: Swallow with water, with or without food, at the same time daily.
• General Information:
  • Avoid if allergic to Atenolol or other beta-blockers.
  • Inform your doctor if you are pregnant, planning pregnancy, or breastfeeding.
  • If you miss a dose, take it as soon as you remember, unless it’s almost time for the next dose.

Drug Interactions:

• With Other Medications: Atenolol may interact with calcium channel blockers, NSAIDs, or diabetes medications.
• With Food: Avoid excessive alcohol as it can increase dizziness.

Regulatory Approval & Manufacturer:
Approved by [Authority], manufactured by [Manufacturer].

Antidotes (If Overdose or Misuse):
Symptoms of overdose include fainting, very slow heart rate, or severe dizziness. Seek emergency medical attention. Supportive care and specific interventions like atropine or glucagon may be administered.

For Pharmacists:

Medicine Name: Blokium
Brand: Blokium
Active Ingredient(s): Atenolol

Indications:

• Hypertension management.
• Chronic stable angina treatment.
• Prevention of myocardial infarction in high-risk individuals.

Pharmacodynamics:

• Mechanism of Action:
  • Atenolol selectively inhibits beta-1 adrenergic receptors, leading to reduced heart rate, myocardial contractility, and cardiac output.
• Pharmacological Effects:
  • Decreased cardiac workload and oxygen demand.
  • Lowered systemic blood pressure.
• Receptor Binding:
  • High specificity for beta-1 adrenergic receptors in the heart.

Pharmacokinetics:

• Absorption:
  • Oral bioavailability ~50%.
• Distribution:
  • Low lipid solubility, limited CNS penetration, and low plasma protein binding (~6–16%).
• Metabolism:
  • Minimal hepatic metabolism; majority excreted unchanged.
• Elimination:
  • Primarily renal clearance; half-life of 6–9 hours.
• Effect of Food:
  • Food does not significantly affect absorption.

Dosage and Administration:

• Adults:
  • Typical dose: 50 mg once daily; adjust based on response and tolerability.
• Pediatric Use:
  • Not recommended.
• Special Populations:
  • Dose adjustments may be required for renal impairment or elderly patients.

Contraindications:

• Hypersensitivity to Atenolol.
• Bradycardia, cardiogenic shock, or severe hypotension.
• Untreated pheochromocytoma or metabolic acidosis.

Warnings and Precautions:

• Caution in patients with diabetes, asthma, or renal impairment.
• Monitor for signs of heart failure, bradycardia, or hypotension.

Drug-Drug Interactions:

• Increased risk of bradycardia with calcium channel blockers (e.g., verapamil).
• May reduce the effectiveness of insulin or oral hypoglycemic agents.
• NSAIDs may reduce the antihypertensive effect.

Drug-Food Interactions:

• Alcohol may enhance the blood pressure-lowering effects, increasing the risk of dizziness or fainting.

Adverse Reactions:

• Common: Dizziness, cold extremities, fatigue, and bradycardia.
• Serious: Severe hypotension, heart block, or bronchospasm.

Therapeutic Effects:

• Effective in controlling blood pressure and angina symptoms, and reducing cardiovascular risks.

Storage:
Store below 30°C, in a dry place, away from sunlight.

Packaging:
Blister packs containing 30 tablets (50 mg each).

Clinical Considerations:

• Pregnancy Category: D (May harm the fetus; use only if essential).
• Lactation: Atenolol is present in breast milk; breastfeeding is not recommended.
• Geriatric Use: Dose adjustments may be needed based on renal function.
• Renal Impairment: Dosage adjustment is required for patients with reduced creatinine clearance.

Conclusion:

Blokium 50 mg is an effective and widely used beta-blocker for managing hypertension and angina. Adherence to prescribed dosage and awareness of side effects and interactions are crucial for achieving the best therapeutic outcomes. Regular monitoring and consultation with healthcare professionals are advised.