Drug Amper Tab 10/4mg 10s Overview

• Brand Name: Amper
• Generic Name: Amlodipine and Perindopril
• Active Ingredient(s): Amlodipine 10mg, Perindopril 4mg

For the General Public:

Uses:
Amper Tab is used to treat hypertension (high blood pressure) and cardiovascular conditions such as atherosclerosis. It is also beneficial for patients with type 2 diabetes-induced hypertension. The combination of Amlodipine and Perindopril works together to lower blood pressure and reduce the risk of heart attacks, strokes, and kidney damage.

• Dosage:
  Take 1 tablet of Amper 10/4mg daily, with or without food. Always follow the dosage instructions provided by your doctor or as per the packaging.
• Possible Side Effects:
  Common side effects may include dizziness, headache, nausea, dry mouth, and stomach upset. If you experience any unusual symptoms, consult your healthcare provider.
  • Common Side Effects:
    • Dizziness
    • Nausea
    • Dry mouth
    • Abdominal pain
  • Serious (Less Common) Side Effects:
    • Swelling in the hands or feet
    • Severe drop in blood pressure
    • Persistent vomiting and nausea
    • Chest pain
    • Unusual tiredness or weakness
• Important Information:
  • Dosage Instruction:
    Follow the prescribed dosage of 1 tablet daily.
  • Usage Instruction:
    This medication can be taken with or without food.
  • General Information:
    • Do not take if allergic to Amlodipine or Perindopril, or have a history of kidney disease, liver issues, or electrolyte imbalances.
    • Consult your doctor if pregnant or breastfeeding.
    • Keep out of reach of children.
    • If you miss a dose, take it as soon as you remember unless it’s almost time for the next dose. Do not double the dose.
• Drug Interactions:
  • Interactions with Other Medications:
    • May interact with other blood pressure medications, potassium supplements, or nonsteroidal anti-inflammatory drugs (NSAIDs).
  • Interactions with Food:
    • No significant food interactions noted, but it’s advisable to take the drug with food to avoid stomach upset.
• Regulatory Approval & Manufacturer:
  Marketed by Next Pharmaceuticals (Pvt) Ltd.
• Antidotes (If Overdose or Misused):
  There is no specific antidote for an overdose of Amper. Supportive treatment is recommended, including symptomatic management and monitoring of vital functions.

For Pharmacists:

• Medicine Name: Amper Tab 10/4mg
• Brand: Amper
• Active Ingredient(s): Amlodipine (10mg), Perindopril (4mg)
• Indications:
  Indicated for the management of hypertension, atherosclerosis, and type 2 diabetes-induced hypertension.
• Pharmacodynamics:
  • Mechanism of Action:
    Amlodipine is a calcium channel blocker that relaxes blood vessels, while Perindopril is an ACE inhibitor that reduces the production of angiotensin II, which constricts blood vessels. Together, they help lower blood pressure.
  • Pharmacological Effects:
    • Lowers blood pressure
    • Reduces the risk of heart attack and stroke
    • Helps prevent kidney damage in diabetic patients
  • Receptor Binding:
    Perindopril inhibits angiotensin-converting enzyme (ACE), while Amlodipine acts on the L-type calcium channels.
• Pharmacokinetics:
  • Absorption:
    Amlodipine is well absorbed orally, with peak plasma concentration in 6-12 hours. Perindopril is also absorbed well and converted into its active form, perindoprilat.
  • Distribution:
    Amlodipine has a volume of distribution of about 21 L/kg, while Perindopril has a large volume of distribution.
  • Metabolism:
    Amlodipine is metabolized by the liver (CYP3A4 enzyme), and Perindopril is metabolized to its active metabolite, perindoprilat, mainly in the liver.
  • Elimination:
    Amlodipine is excreted mainly through urine, while Perindopril is excreted as perindoprilat.
  • Half-Life:
    Amlodipine’s half-life is approximately 30-50 hours, while Perindopril has a half-life of about 17-36 hours.
  • Bioavailability:
    Amlodipine has about 64-80% bioavailability, and Perindopril has about 60-70% bioavailability.
  • Time to Peak Concentration:
    Peak plasma concentration for Amlodipine is reached in 6-12 hours, while Perindopril reaches peak concentration in 3-4 hours.
  • Effect of Food:
    Food does not significantly affect the absorption of either drug.
• Dosage and Administration:
  • Adults:
    Typically, one tablet daily for hypertension.
  • Pediatric:
    Not recommended for children under 17.
  • Special Populations:
    Dose adjustments may be necessary for elderly patients or those with renal impairment.
• Contraindications:
  • Known hypersensitivity to Amlodipine or Perindopril
  • History of severe liver disease or renal impairment
• Warnings and Precautions:
  • Use cautiously in patients with heart failure, liver disease, or renal issues.
  • Monitor renal function and blood pressure regularly.
• Drug-Drug Interactions:
  • Avoid combining with other ACE inhibitors or ARBs to prevent excessive lowering of blood pressure.
• Drug-Food Interactions:
  No significant food-drug interactions.
• Adverse Reactions:
  • Common:
    Dizziness, headache, nausea, and stomach upset.
  • Serious:
    Hypotension, angioedema, and severe allergic reactions.
• Therapeutic Effects:
  Helps reduce blood pressure and prevent cardiovascular events such as heart attacks and strokes.
• Storage:
  Store at room temperature (15-30°C) in a dry, light-protected container.
• Packaging:
  Available in tablet form, typically in packs of 10.
• Clinical Considerations:
  • Pregnancy Category: Category C (consult a doctor before use during pregnancy).
  • Lactation Category: Not recommended during breastfeeding.
  • Pediatric: Not recommended for use in children under 17.
  • Geriatric: Use with caution, especially in those with renal or liver impairment.

Conclusion:

Amper Tab 10/4mg is an effective treatment for hypertension and cardiovascular conditions. When used as prescribed, it can help manage symptoms and reduce the risk of heart-related complications. Patients should follow proper dosage instructions and be aware of potential side effects. It is important to consult a healthcare provider if there are concerns or unusual symptoms.