Brand Name: Actim
Generic Name: Bisoprolol Fumarate
Active Ingredient(s): Bisoprolol Fumarate 5 mg

For the General Public:

Uses:
Actim is commonly used to treat:

• High blood pressure (hypertension).
• Chronic stable angina (chest pain).
• Heart failure, in some cases.

It works by slowing the heart rate and relaxing blood vessels, which helps to improve blood flow and reduce blood pressure.

Dosage:

• Typically, one tablet (5 mg) once daily, taken in the morning.
• Dosage may be adjusted by your doctor depending on your condition.

Possible Side Effects:

• Common Side Effects:
  • Fatigue, dizziness, headache, and nausea.
  • Cold hands or feet.
• Serious (Less Common) Side Effects:
  • Difficulty breathing, swelling of the legs, or rapid weight gain.
  • Severe bradycardia (slow heart rate).

Important Information:

• Dosage Instruction: Take exactly as prescribed by your doctor. Do not stop abruptly without medical advice.
• Usage Instruction: Take with or without food. Swallow the tablet whole with water.
• General Information:
  • Do not take this medicine if you are allergic to bisoprolol or other beta-blockers.
  • Inform your doctor if you have asthma, severe heart conditions, or kidney/liver problems.
  • If pregnant or breastfeeding, consult your healthcare provider before use.

Drug Interactions:

• Interactions with Other Medications:
  • May interact with other blood pressure medicines, antiarrhythmics, or medications for diabetes.
  • Avoid taking with calcium channel blockers (e.g., verapamil, diltiazem) without medical advice.
• Interactions with Food:
  • Avoid excessive alcohol consumption as it may increase dizziness or drowsiness.

Regulatory Approval & Manufacturer:
Approved by [regulatory authority], manufactured by [manufacturer].

Antidotes (If Overdose or Misuse):

• Overdose may lead to severe bradycardia, hypotension, or heart block. Seek emergency medical attention. Treatments include supportive measures such as atropine or glucagon.

For Pharmacists:

Medicine Name: Actim
Brand: Actim
Active Ingredient(s): Bisoprolol Fumarate 5 mg

Indications:

• Management of hypertension.
• Treatment of chronic stable angina.
• Supportive therapy for chronic heart failure.

Pharmacodynamics:

• Mechanism of Action:
  Bisoprolol is a selective beta-1 adrenergic receptor blocker. It decreases heart rate, myocardial contractility, and cardiac output, leading to reduced blood pressure and oxygen demand.
• Pharmacological Effects:
  • Reduces heart workload.
  • Decreases blood pressure.
  • Improves exercise tolerance in angina patients.
• Receptor Binding:
  Selectively binds to beta-1 adrenergic receptors in cardiac tissue, reducing adrenergic stimulation and leading to therapeutic effects.

Pharmacokinetics:

• Absorption: Rapidly absorbed after oral administration, with bioavailability of approximately 90%.
• Distribution: Widely distributed, minimal crossing of the blood-brain barrier.
• Metabolism: Partially metabolized in the liver.
• Elimination: Excreted equally via urine and feces.
• Half-Life: 10-12 hours.
• Effect of Food: Food does not significantly affect drug absorption.

Dosage and Administration:

• Adults: 5 mg once daily; maximum dose is 20 mg/day.
• Pediatric: Not recommended.
• Special Populations:
  • Renal Impairment: Start with a lower dose; monitor renal function.
  • Hepatic Impairment: Use with caution; adjust dose as necessary.

Contraindications:

• Known hypersensitivity to bisoprolol or beta-blockers.
• Severe bradycardia, cardiogenic shock, or heart block.
• Untreated pheochromocytoma or severe asthma.

Warnings and Precautions:

• Use cautiously in patients with diabetes as it may mask symptoms of hypoglycemia.
• Avoid abrupt discontinuation to prevent rebound hypertension or angina.

Drug-Drug Interactions:

• Increased risk of bradycardia or hypotension with other antihypertensives or antiarrhythmics.
• Enhanced effects with calcium channel blockers (e.g., verapamil, diltiazem).
• Use cautiously with NSAIDs as they may reduce antihypertensive effects.

Drug-Food Interactions:

• Food has no significant effect on absorption, but excessive alcohol may increase side effects like dizziness.

Adverse Reactions:

• Common: Fatigue, dizziness, nausea, headache.
• Serious: Severe bradycardia, heart failure, bronchospasm in susceptible individuals.

Therapeutic Effects:

• Lowers blood pressure and reduces heart rate, relieving symptoms of hypertension and angina.

Storage:
Store at 15-30°C in a dry place, protected from light and moisture.

Packaging:
Blister pack containing 14 tablets.

Clinical Considerations:

• Pregnancy Category: C (Use only if benefits outweigh risks).
• Lactation: Excreted in breast milk; use with caution.
• Pediatric: Not recommended for use in children.
• Geriatric: Start with a lower dose and monitor closely.

Conclusion:

Actim Tab 5 mg is an effective beta-blocker used for managing hypertension, angina, and certain cases of heart failure. When used as directed, it can improve cardiovascular health and prevent complications. Proper monitoring and adherence to prescribed regimens are crucial for its safe use. Always consult a healthcare professional for any concerns or adverse effects.