Acelar Tab 10 mg 2×10’s-Potential Overview:

Brand Name: Acelar
Generic Name: Amlodipine
Active Ingredient(s): Amlodipine Besylate 10 mg

For the General Public:

Uses:
Acelar 10 mg is used to:

• Treat high blood pressure (hypertension).
• Prevent and manage chest pain (angina).
• Lower the risk of heart attack and stroke.

How It Works:
Amlodipine is a calcium channel blocker that relaxes and widens blood vessels, improving blood flow and reducing blood pressure.

Dosage:

• Adults: One 10 mg tablet once daily, with or without food.
• Children (6–17 years): Dose adjusted by the doctor, generally 5 mg per day.
• Maximum Dose: 10 mg daily.

Possible Side Effects:

• Common Side Effects: Swelling (edema), headache, fatigue, dizziness, nausea, and flushing.
• Serious Side Effects: Severe low blood pressure, rapid heart rate, or allergic reactions (e.g., swelling of face, lips, tongue).

Important Information:

• Dosage Instruction: Take one tablet daily at the same time each day.
• Usage Instruction: Can be taken with or without food. Avoid grapefruit or grapefruit juice.
• General Information:
  • Do not take if allergic to amlodipine or similar medications.
  • Consult a doctor if pregnant, breastfeeding, or taking other medications.
  • Do not stop the medication without medical advice.

Drug Interactions:

• With Other Medications: Enhanced blood pressure reduction with other antihypertensives; increased side effects with antifungals or certain antibiotics.
• With Food: Grapefruit juice may increase amlodipine levels, raising the risk of side effects.

Regulatory Approval & Manufacturer:
Approved by [authority], manufactured by [manufacturer].

Antidotes (If Overdose or Misuse):
Symptoms include severe hypotension and dizziness. Seek immediate medical care for supportive treatment like IV fluids and vasopressors.

For Pharmacists:

Medicine Name: Acelar
Brand: Acelar
Active Ingredient(s): Amlodipine Besylate 10 mg

Indications:

• Hypertension
• Chronic stable angina and vasospastic angina (Prinzmetal’s angina)
• Prevention of cardiovascular complications

Pharmacodynamics:

• Mechanism of Action:
  Amlodipine inhibits calcium ion influx into vascular smooth muscle and cardiac muscle cells, leading to vasodilation and reduced peripheral vascular resistance.
• Pharmacological Effects:
  • Lowers blood pressure.
  • Improves coronary oxygen supply.
• Receptor Binding:
  Binds to L-type calcium channels, inhibiting calcium influx and promoting smooth muscle relaxation.

Pharmacokinetics:

• Absorption: Well absorbed orally; bioavailability is 60–80%.
• Distribution: Extensively bound to plasma proteins (~93%).
• Metabolism: Metabolized in the liver to inactive metabolites.
• Elimination: Excreted via urine; elimination half-life is 30–50 hours.
• Effect of Food: Food does not significantly affect absorption.

Dosage and Administration:

• Adults: 10 mg once daily.
• Pediatric (6–17 years): 5–10 mg once daily as directed.
• Special Populations: Use cautiously in elderly or hepatic impairment; start with a lower dose if necessary.

Contraindications:

• Hypersensitivity to amlodipine or other dihydropyridines.
• Severe hypotension or shock.

Warnings and Precautions:

• Use with caution in severe hepatic impairment, heart failure, or aortic stenosis.
• Monitor blood pressure and signs of peripheral edema.

Drug-Drug Interactions:

• Interaction with CYP3A4 inhibitors (e.g., ketoconazole) can increase amlodipine levels.
• CYP3A4 inducers (e.g., rifampin) may reduce efficacy.

Drug-Food Interactions:

• Grapefruit juice increases amlodipine levels, enhancing side effects.

Adverse Reactions:

• Common: Peripheral edema, headache, dizziness, palpitations, fatigue.
• Serious: Severe hypotension, angina exacerbation, and allergic reactions.

Therapeutic Effects:

• Lowers blood pressure and reduces the workload on the heart.
• Prevents complications like heart attack and stroke.

Storage:
Store at 15–30°C, away from light and moisture.

Packaging:
Available in 2×10 tablets (10 mg each).

Clinical Considerations:

• Pregnancy Category: C (use only if necessary).
• Lactation: Use cautiously; may pass into breast milk.
• Pediatric Use: Suitable for children aged 6–17 years under medical supervision.
• Geriatric Use: Start with a lower dose due to increased sensitivity.

Conclusion:

Acelar 10 mg Tab 2×10’s is a highly effective calcium channel blocker for managing hypertension and angina. Regular use under proper medical supervision can significantly improve cardiovascular health. Pharmacists should emphasize avoiding grapefruit juice and educate patients on recognizing side effects.