Zoltar Insta Cap 40/1100mg (Omeprazole and Sodium Bicarbonate)-Potential Overview

• Brand Name: Zoltar Insta
• Generic Name: Omeprazole and Sodium Bicarbonate
• Strength: 40 mg of Omeprazole and 1100 mg of Sodium Bicarbonate per capsule
• Pack Size: 14 capsules per pack

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Zoltar Insta Cap 40/1100mg (Omeprazole and Sodium Bicarbonate) is a combination medication used to treat various stomach acid-related conditions such as GERD (gastroesophageal reflux disease), erosive esophagitis, and duodenal ulcers.

Composition:

• Omeprazole (40 mg): A proton pump inhibitor (PPI) that reduces stomach acid by inhibiting the proton pump (H+/K+ ATPase) in the stomach lining.
• Sodium Bicarbonate (1100 mg): An antacid that neutralizes stomach acid, helping to relieve acid-related discomfort immediately.

Mechanism of Action:

1. Omeprazole: Acts on the proton pump in the parietal cells of the stomach, reducing acid production and providing longer-term acid suppression.
2. Sodium Bicarbonate: Provides immediate relief by neutralizing gastric acid and increasing the stomach’s pH.

Indications:

• Gastroesophageal reflux disease (GERD): Reduces acid reflux, which helps in healing the esophagus.
• Peptic ulcers: Helps in the healing and prevention of gastric and duodenal ulcers.
• Erosive Esophagitis: Reduces inflammation in the esophagus caused by stomach acid.

Drug Interactions:

• Omeprazole: Interacts with medications such as warfarin, diazepam, phenytoin, and clopidogrel, potentially altering their effects.
• Sodium Bicarbonate: Can interact with other drugs by altering stomach pH, which may affect the absorption of certain medications.

Precautions:

• Patients with liver or kidney issues should use this medication cautiously.
• Long-term use may increase the risk of bone fractures, infections, and kidney problems.
• The product should be taken on an empty stomach for optimal absorption.

For further details on the medication’s side effects, contraindications, or full prescribing information, it’s best to consult a healthcare provider or review the official product information from the manufacturer

Pharmacist Related Data

Chemical Names and Formulas:

• Omeprazole:
  • Chemical Name: 5-Methoxy-2-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methylthio]-1H-benzimidazole.
  • Molecular Formula: C₁₉H₁₉N₃O₅S
• Sodium Bicarbonate:
  • Chemical Name: Sodium bicarbonate.
  • Molecular Formula: NaHCO₃

Pharmacodynamics:

• Omeprazole:
  Omeprazole is a proton pump inhibitor (PPI) that inhibits the H+/K+ ATPase enzyme in the stomach lining, responsible for the final step of acid production. This effectively lowers gastric acid secretion, leading to a reduction in acidity in the stomach and relief from acid-related symptoms like heartburn and ulcers.
• Sodium Bicarbonate:
  Sodium bicarbonate is an antacid that neutralizes stomach acid directly. It increases the gastric pH, providing quick relief from symptoms like heartburn and indigestion. It also helps in improving the absorption of omeprazole by neutralizing the acidic environment that could interfere with its efficacy.

Pharmacokinetics:

1. Absorption:
   • Omeprazole is well-absorbed from the small intestine but is protected from stomach acid by an enteric coating. This allows for effective absorption after the capsule dissolves in the intestine.
   • The bioavailability of omeprazole is about 35-40%, but it increases to 60-70% with repeated doses.
   • Sodium bicarbonate quickly neutralizes gastric acid, facilitating a favorable pH environment for the absorption of omeprazole.
2. Distribution:
   • Omeprazole is highly protein-bound (about 95%), and is distributed throughout the body, especially accumulating in the stomach lining where it exerts its therapeutic effect.
   • Sodium bicarbonate does not significantly affect drug distribution as it is an antacid used to neutralize gastric acid.
3. Metabolism:
   • Omeprazole is primarily metabolized in the liver by the cytochrome P450 enzymes, particularly CYP2C19 and CYP3A4. It is metabolized into inactive metabolites, which are then excreted in the urine.
   • Sodium bicarbonate does not require metabolic processes; it acts directly as a buffer to neutralize acid.
4. Half-life:
   • Omeprazole has a short half-life of 0.5–1 hour, but its acid-suppressing effect lasts up to 24 hours due to its irreversible inhibition of the proton pump.
   • Sodium bicarbonate is rapidly absorbed and eliminated, so it doesn’t contribute to long-term effects.
5. Excretion:
   • Both omeprazole and its metabolites are excreted through the urine, while sodium bicarbonate is excreted via the kidneys.

Drug Interactions:

1. Interactions with Other Medications:
   • Omeprazole:
     • Can interfere with the absorption of drugs that require an acidic environment, such as ketoconazole, iron salts, and digoxin.
     • Omeprazole may reduce the activation of clopidogrel, reducing its effectiveness in preventing clots.
     • It increases the plasma concentration of drugs metabolized by CYP2C19, including warfarin, phenytoin, and diazepam.
   • Sodium Bicarbonate:
     • Alters the pH of the stomach and can affect the absorption of medications that depend on gastric acidity.
     • It may also increase the absorption of certain drugs, such as aspirin and amphetamines, potentially leading to toxicity in some cases.
2. Interactions with Food:
   • Omeprazole is best absorbed when taken before meals (preferably on an empty stomach) because food can reduce its bioavailability.
   • Sodium bicarbonate can also affect the gastric pH, which may alter the absorption of other medications taken at the same time.