Brand Name: Bronchilate

Generic Name: Salbutamol

Active Ingredient(s): Salbutamol (4 mg)

For the General Public:

Uses:

Bronchilate 4 mg is used for:

• Relief of bronchospasm in conditions such as asthma, chronic bronchitis, and emphysema.
• Prevention of exercise-induced bronchospasm.

How It Works:

Bronchilate contains salbutamol, a beta-2 adrenergic receptor agonist that relaxes the muscles in the airways, making breathing easier.

Dosage:

• Typical dose: 2–4 mg taken three to four times daily or as directed by a healthcare provider.

Possible Side Effects:

• Common Side Effects: Tremors, headache, dizziness, palpitations, or nervousness.
• Serious Side Effects: Severe allergic reactions, chest pain, irregular heartbeat, or worsening of breathing difficulties. Contact a doctor immediately if you experience these.

Important Information:

• Dosage Instruction: Follow your doctor’s instructions. Do not exceed the prescribed dose.
• Usage Instruction:
  • Take with or without food.
  • Avoid using other bronchodilators without consulting a doctor.
• General Information:
  • Consult your doctor if you are pregnant, breastfeeding, or planning pregnancy.
  • Keep out of reach of children.

Drug Interactions:

• With Other Medications:
  • Avoid using with non-selective beta-blockers (e.g., propranolol).
  • Increased risk of side effects when used with other sympathomimetic drugs.
• With Food:
  • No significant interactions with food, but consult your healthcare provider for dietary advice.

Regulatory Approval & Manufacturer:

• Approved by [Regulatory Authority] and manufactured by [Manufacturer].

Antidotes (If Overdose or Misuse):

• Administer beta-blockers (e.g., propranolol) with caution in cases of overdose. Monitor heart rate and provide supportive care as needed.

For Pharmacists:

Medicine Name: Bronchilate

Brand: Bronchilate
Active Ingredient(s): Salbutamol

Indications:

• Management of bronchospasm in asthma and other obstructive airway diseases.
• Prevention of exercise-induced bronchospasm.

Pharmacodynamics:

• Mechanism of Action:
  Salbutamol selectively stimulates beta-2 adrenergic receptors in the airway smooth muscle, leading to relaxation of bronchial muscles and reduced airway resistance.
• Pharmacological Effects:
  • Bronchodilation and improved airflow.
  • Relieves symptoms such as wheezing and shortness of breath.
• Receptor Binding:
  High affinity for beta-2 adrenergic receptors, resulting in targeted bronchodilatory effects.

Pharmacokinetics:

• Absorption: Rapidly absorbed, with onset of action within 30 minutes.
• Distribution: Widely distributed, ~10% bound to plasma proteins.
• Metabolism: Metabolized in the liver to inactive metabolites.
• Elimination: Excreted via urine (as metabolites and unchanged drug).
• Half-Life: Approximately 4–6 hours.

Dosage and Administration:

• Adults and Adolescents: 2–4 mg three to four times daily.
• Special Populations:
  • Renal Impairment: Use with caution and monitor side effects.
  • Hepatic Impairment: Adjust dose as necessary.

Contraindications:

• Hypersensitivity to salbutamol or excipients.
• Patients with severe cardiovascular disorders.

Warnings and Precautions:

• Use cautiously in patients with hyperthyroidism, diabetes, or cardiovascular diseases.
• Monitor potassium levels, as hypokalemia may occur.
• Do not exceed recommended doses to avoid systemic side effects.

Drug-Drug Interactions:

• Beta-Blockers: May antagonize the effects of salbutamol.
• MAO Inhibitors: Increased risk of cardiovascular side effects.
• Diuretics: May enhance the risk of hypokalemia.

Drug-Food Interactions:

• No significant food interactions, but high caffeine intake may exacerbate side effects like nervousness or palpitations.

Adverse Reactions:

• Common: Tremor, palpitations, tachycardia, nervousness, and headache.
• Serious: Paradoxical bronchospasm, arrhythmias, and severe hypokalemia.

Therapeutic Effects:

• Provides rapid relief of bronchospasm.
• Improves respiratory function and exercise tolerance.

Storage:

• Store at 20–25°C, away from moisture and direct sunlight.

Packaging:

• Available in blister packs of 100 tablets (4 mg each).

Clinical Considerations:

• Pregnancy Category: C (Use only if benefits outweigh risks).
• Lactation: Use cautiously; small amounts may be excreted in breast milk.
• Pediatric Use: Consult a specialist for dosing in children.
• Geriatric Use: Initiate at lower doses to minimize side effects.

Conclusion:

Bronchilate 4 mg is an effective bronchodilator for managing asthma and bronchospasm. Proper adherence to dosing instructions ensures optimal relief while minimizing risks. Consult a healthcare professional for tailored advice.