Brand Name: Brodin

Generic Name: Metamizole Sodium (Dipyrone)

Active Ingredient(s): Metamizole Sodium (500 mg)

For the General Public:

Uses:

Brodin 500 mg is used for:

• Relief of moderate to severe pain (e.g., headache, toothache, or muscle pain).
• Treatment of fever when other antipyretics are ineffective.
• Management of pain in conditions such as colic or post-surgical pain.

How It Works:

Brodin contains metamizole sodium, a non-opioid analgesic and antipyretic. It works by inhibiting prostaglandin synthesis, reducing pain and lowering fever.

Dosage:

• Take one tablet 2–3 times daily or as directed by your healthcare provider.
• Do not exceed the maximum recommended dose of 4 grams per day.

Possible Side Effects:

• Common Side Effects: Nausea, dizziness, or rash.
• Serious Side Effects: Allergic reactions, difficulty breathing, or agranulocytosis (a rare but severe drop in white blood cells). Contact a doctor immediately if you experience these symptoms.

Important Information:

• Dosage Instruction: Follow your doctor’s recommendations strictly. Avoid exceeding the prescribed dose.
• Usage Instruction:
  • Take with or after food to minimize stomach upset.
  • Drink plenty of water when taking the tablet.
• General Information:
  • Not recommended for long-term use due to the risk of serious blood-related side effects.
  • Consult your doctor before use if pregnant, breastfeeding, or planning pregnancy.
  • Keep out of reach of children.

Drug Interactions:

• With Other Medications:
  • May enhance the effects of anticoagulants and increase the risk of bleeding.
  • Avoid combining with other NSAIDs to prevent excessive side effects.
• With Food:
  • Food does not significantly alter the effectiveness of Brodin, but taking it with food may reduce stomach irritation.

Regulatory Approval & Manufacturer:

• Approved by [Regulatory Authority] and manufactured by [Manufacturer].

Antidotes (If Overdose or Misuse):

• Provide supportive care and symptomatic treatment.
• Activated charcoal may be administered if the overdose is recent.
• Seek immediate medical attention in case of overdose.

For Pharmacists:

Medicine Name: Brodin

Brand: Brodin
Active Ingredient(s): Metamizole Sodium

Indications:

• Pain relief in moderate to severe pain conditions.
• Fever reduction when standard treatments are inadequate.

Pharmacodynamics:

• Mechanism of Action:
  Metamizole inhibits the cyclooxygenase (COX) enzyme, reducing prostaglandin production, which decreases pain sensitivity and fever.
• Pharmacological Effects:
  • Provides potent analgesic and antipyretic effects.
  • Mild anti-inflammatory action.
• Receptor Binding:
  Acts indirectly by reducing prostaglandin-mediated sensitization of pain receptors, without directly binding to COX active sites.

Pharmacokinetics:

• Absorption: Rapidly absorbed after oral administration.
• Distribution: Extensively distributed in tissues; crosses the blood-brain barrier.
• Metabolism: Metabolized in the liver into active metabolites.
• Elimination: Excreted primarily via urine.
• Half-Life: Approximately 1–4 hours.

Dosage and Administration:

• Adults: 500 mg every 6–8 hours as needed. Maximum daily dose: 4 grams.
• Special Populations:
  • Renal Impairment: Use with caution; dose adjustment may be required.
  • Hepatic Impairment: Monitor liver function; adjust dose as necessary.

Contraindications:

• Hypersensitivity to metamizole or other pyrazolone derivatives.
• Severe liver or kidney dysfunction.
• Blood disorders (e.g., agranulocytosis).

Warnings and Precautions:

• Risk of agranulocytosis with prolonged use; monitor blood counts during therapy.
• Use cautiously in patients with asthma or allergic conditions.
• Discontinue immediately if signs of allergic reactions or blood disorders occur.

Drug-Drug Interactions:

• Anticoagulants: Increased risk of bleeding.
• Other NSAIDs: Enhanced gastrointestinal side effects.
• CYP450 Inducers/Inhibitors: May alter the metabolism of metamizole.

Drug-Food Interactions:

• Food does not significantly affect drug absorption but taking Brodin with meals can reduce the risk of gastrointestinal irritation.

Adverse Reactions:

• Common: Nausea, vomiting, headache, rash.
• Serious: Agranulocytosis, anaphylaxis, Stevens-Johnson syndrome.

Therapeutic Effects:

• Effective in reducing pain and fever in various conditions.

Storage:

• Store at 20–25°C, protected from light and moisture.

Packaging:

• Available in blister packs of 10 tablets per strip.

Clinical Considerations:

• Pregnancy Category: C (Avoid unless absolutely necessary).
• Lactation: Metabolites may be excreted in breast milk; use caution.
• Pediatric Use: Not recommended for children under 12 years without specialist advice.
• Geriatric Use: Use with caution, especially in the presence of comorbid conditions.

Conclusion:

Brodin 500 mg is a potent analgesic and antipyretic for short-term use in managing pain and fever. Adherence to dosage instructions and monitoring for side effects ensures safe and effective therapy. Always consult a healthcare professional for personalized guidance.