Avil 25Mg Tab 250 s-Potential Overview

• Brand Name: Avil
• Generic Name: Pheniramine Maleate
• Active Ingredient(s): Pheniramine Maleate

For the General Public:

Uses:
This medicine is commonly used to treat allergic conditions, including hay fever, allergic rhinitis, and skin allergies. It works by blocking histamine receptors, which reduces symptoms of allergy, such as sneezing, itching, and runny nose.

Dosage:
Take 1 tablet 2-3 times a day with or without food. Always follow the instructions on the packaging or as prescribed by your doctor.

Possible Side Effects:
Some common side effects may include drowsiness, dizziness, dry mouth, and nausea. If you experience anything unusual, contact your healthcare provider.

Common Side Effects:

• Drowsiness
• Dizziness
• Dry mouth
• Nausea

Serious (Less Common) Side Effects:

• Difficulty breathing
• Severe allergic reactions
• Fast or irregular heartbeat

Important Information:
Do not take this medicine if you are allergic to pheniramine or have a history of severe respiratory issues.
If you are pregnant, breastfeeding, or planning to become pregnant, consult your doctor before use.
Keep out of reach of children.
If you miss a dose, take it as soon as you remember unless it’s almost time for the next dose. Do not double the dose.

Drug Interactions:

Interactions with Medicine:
Interactions with other medications include alcohol, sedatives, and other antihistamines. Inform your healthcare provider of all the medications you are taking.

Interactions with Food:
No significant interactions with food.

Regulatory Approval & Manufacturer:

• Manufacturer: Cadila Healthcare (Zydus)
• Regulatory Approval: Approved by regulatory bodies for use in many countries.

Antidotes (If Over Dosage or Misused by Patients):
In case of overdose, contact poison control or seek immediate medical attention. Symptoms of overdose may include severe drowsiness, confusion, or seizures.

For Pharmacists

Medicine Name: Avil 25mg Tablet
Brand: Avil
Active Ingredient(s): Pheniramine Maleate

Indications:
Indicated for the management of allergic reactions such as hay fever, allergic rhinitis, urticaria, and conjunctivitis.

Pharmacodynamics:
Mechanism of Action:
Pheniramine maleate is an antihistamine that acts by blocking histamine receptors (H1 receptors) to alleviate allergy symptoms.

Pharmacological Effects:

• Reduces histamine-induced effects like swelling and itching
• Relieves nasal congestion and sneezing

Receptor Binding:
Pheniramine binds to histamine H1 receptors, inhibiting the action of histamine, a substance involved in allergic reactions.

Pharmacokinetics:
Absorption: Rapidly absorbed after oral administration.
Distribution: Distributed throughout the body with a high affinity for plasma proteins.
Metabolism: Metabolized in the liver through cytochrome P450 enzymes.
Elimination: Primarily excreted in urine.
Half-Life: Approximately 12-15 hours.
Bioavailability: Around 50%.
Time to Peak Concentration: Approximately 2-3 hours.
Effect of Food: Food does not significantly alter absorption.

Dosage and Administration:
Adults: 25mg 2-3 times daily as prescribed.
Pediatric: Not recommended for children under 6 years without medical guidance.
Special Populations:

• Elderly: Use with caution in elderly patients.
• Hepatic or Renal Impairments: Dose adjustments may be necessary.

Contraindications:

• Hypersensitivity to pheniramine maleate or excipients.
• Contraindicated in patients with glaucoma, severe liver disease, or bladder neck obstruction.

Warnings and Precautions:

• Use with caution in patients with asthma, chronic obstructive pulmonary disease (COPD), or cardiovascular disease.
• Monitor for adverse effects like sedation and dry mouth.

Drug-Drug Interactions:

• Alcohol, sedatives, and other CNS depressants may enhance sedative effects.
• Avoid combining with other antihistamines to prevent overdose.

Drug-Food Interactions:

• No significant food interactions noted.

Adverse Reactions:
Common:

• Drowsiness
• Dry mouth
• Dizziness

Serious:

• Anaphylaxis
• Respiratory depression
• Seizures

Therapeutic Effects:
Reduces allergic symptoms such as sneezing, itching, and runny nose.

Storage:
Store at room temperature (20–25°C), in an airtight container.
Packaging:
Available in 25mg tablets, in packs of 250 tablets.

Clinical Considerations:
Pregnancy Category: Category C (Risk cannot be ruled out).
Lactation Category: Consult a doctor before use during breastfeeding.
Pediatric Category: Not recommended for children under 6 years.
Geriatric Category: Use with caution in elderly patients due to potential sedative effects.
Adult Category: Approved for adult use at prescribed dosages.
Child Category: Not recommended for children under 6 years without medical guidance.

Conclusion:
Avil 25mg is an effective treatment for managing allergic conditions such as hay fever and urticaria. It provides symptomatic relief, but it is essential to follow proper dosage instructions to avoid potential side effects. Pharmacists should educate patients on the risk of sedation and drug interactions, especially in special populations such as pregnant women and the elderly.