Amper Tab 10/4mg 10s-Potential Overview

• Brand Name: Amper Tab 10/4mg 10s
• Generic Names: Amlodipine 10mg and Perindopril 4mg
• Pharmaceutical Class:
  • Amlodipine: Calcium channel blocker
  • Perindopril: Angiotensin-converting enzyme (ACE) inhibitor
• Indications for Use:
  • Management of hypertension
  • Reducing the risk of cardiovascular complications like angina and heart attack

Common and Serious Side Effects

Common Side Effects:

• Dizziness
• Headache
• Swelling (edema) in the hands, feet, or ankles
• Dry cough
• Fatigue

Serious (Less Common) Side Effects:

• Chest pain
• Severe allergic reactions
• Rapid heartbeat or palpitations
• Difficulty in breathing
• Angioedema (swelling of lips, tongue, throat)
• Yellowing of skin/eyes, a sign of liver dysfunction

Dosage & Usage Instructions

• Typical Dosage: 1 tablet once daily, as prescribed by a healthcare provider.
• Administration:
  • Can be taken with or without food.
  • Preferably taken with water.

Always follow a physician’s dosage and usage recommendations to manage potential adverse effects.

Drug Interactions

Interactions with Other Medications:

• Amlodipine:
  • NSAIDs, like ibuprofen, may reduce its effectiveness.
  • Drugs that lower blood pressure, e.g., other antihypertensive medications.
• Perindopril:
  • Diuretics, potassium supplements, or potassium-sparing diuretics may lead to elevated potassium levels.
  • Lithium may increase levels in the blood if combined with Perindopril.
  • Nonsteroidal anti-inflammatory drugs (NSAIDs) can impair kidney function when combined.

Interactions with Food:

• Grapefruit juice may inhibit Amlodipine metabolism, increasing its blood pressure-lowering effects.

Always inform the doctor about current medication use or supplements before starting treatment.

Regulatory Approval & Manufacturer

• Regulatory Approval: FDA-approved and other international regulatory bodies
• Manufacturer: Depends on the country (e.g., widely manufactured by pharmaceutical companies like Pfizer, Cipla, etc.)

Pharmacist Data

Drug Name & Chemical Details

• Amlodipine Chemical Name: Amlodipine Besylate
• Perindopril Chemical Name: Perindopril Erbumine

Pharmacodynamics

Mechanism of Action:

• Amlodipine: Blocks calcium from entering vascular smooth muscle, relaxing blood vessels to allow easier blood flow.
• Perindopril: Inhibits the enzyme ACE, which reduces angiotensin II production, leading to vasodilation and reduced blood pressure.

Therapeutic Effects:

• Amlodipine: Lowers blood pressure and relieves angina symptoms.
• Perindopril: Reduces blood pressure, improving outcomes for patients with heart failure or hypertension.

Pharmacokinetics

Absorption:

• Amlodipine: 90% absorbed orally with peak plasma levels within 6 to 12 hours.
• Perindopril: Well-absorbed, with peak effects observed within 3-4 hours.

Distribution:

• Both Amlodipine and Perindopril bind to plasma proteins extensively.

Metabolism:

• Amlodipine is metabolized by the liver into inactive metabolites.
• Perindopril undergoes conversion to its active form (perindoprilat) in the liver.

Excretion:

• Amlodipine is excreted primarily through the urine.
• Perindopril is excreted via urine, predominantly as perindoprilat.

Half-Life:

• Amlodipine: 30 to 50 hours
• Perindopril: 3 to 4 hours (active metabolite perindoprilat has a longer half-life)

Drug Interactions

With Food:

• Avoid grapefruit juice due to its interaction with Amlodipine.

With Other Medications:

• NSAIDs can impair both Amlodipine and Perindopril’s antihypertensive effects.
• Diuretics may lead to hypotension when combined with these medications.

Clinical Considerations

Pregnancy Category:

• Perindopril: Category D (contraindicated during pregnancy)
• Amlodipine should be used cautiously under the supervision of a healthcare provider during pregnancy.

Lactation:

• Not safe for breastfeeding mothers due to potential adverse effects on neonates.

Pediatric Use:

• Limited safety data; not recommended unless directed by a pediatric cardiologist.

Geriatric Use:

• Older adults may experience more pronounced effects like dizziness, hypotension, or kidney impairment. Monitor carefully.

Other Considerations:

• Regular monitoring of kidney function and serum potassium levels is required during treatment.