Amotac Tab 10 Mg 2×10’s-Potential Overview

For the General Public

1. Medicine Name: Amotac 10mg Tablets
2. Brand: Mass Pharmaceuticals
3. Active Ingredient(s): Enalapril Maleate

Uses:

Amotac 10mg is commonly used to treat conditions like hypertension (high blood pressure), symptomatic heart failure, and prevent heart complications in asymptomatic left ventricular dysfunction. It works by relaxing blood vessels, improving blood flow, and lowering blood pressure to reduce the risk of heart attacks, strokes, and kidney problems.

Dosage:

1. Adults (above 18 years): Take 1 tablet (10mg) once daily, or as prescribed by your healthcare provider.
2. Children (below 17 years): Not recommended.

Always follow the instructions on the packaging or as prescribed by your doctor.

Possible Side Effects:

Some common side effects may include:

• Dizziness
• Dry mouth
• Fatigue
• Swelling in the gums
• Sore throat
• Cough

Serious side effects (rare):

• Severe stomach pain
• Yellowing of skin or eyes
• Dark urine
• Irregular heartbeat
• Muscle weakness

If you experience any unusual symptoms, contact your healthcare provider.

Important Information:

1. Do not take Amotac 10mg if you are allergic to its active ingredient, Enalapril Maleate.
2. Avoid alcohol while taking this medication.
3. Use with caution if you have a history of kidney problems, angioedema, or elevated potassium levels.
4. If pregnant or breastfeeding, consult a doctor before use.

Keep out of reach of children. If you miss a dose, take it as soon as possible unless it’s almost time for the next dose. Do not double the dose.

For Pharmacists

Medicine Information:

1. Medicine Name: Amotac 10mg Tablets
2. Brand: Mass Pharmaceuticals
3. Active Ingredient(s): Enalapril Maleate

Indications:

Amotac 10mg is indicated for the management of the following conditions:

1. Hypertension (high blood pressure).
2. Symptomatic heart failure.
3. Asymptomatic left ventricular dysfunction to prevent further heart complications.

Pharmacodynamics

Mechanism of Action:

Amotac contains Enalapril Maleate, which is an Angiotensin-Converting Enzyme (ACE) inhibitor. It inhibits the enzyme responsible for converting Angiotensin I to Angiotensin II, which results in vasodilation, reduced aldosterone release, and lower blood pressure.

Pharmacological Effects:

Amotac exhibits the following effects:

1. Reduces blood pressure by promoting vasodilation.
2. Eases heart failure symptoms by improving cardiac function and lowering cardiac workload.
3. Protects the kidneys by preventing glomerular hypertension.
4. Limits the progression of asymptomatic left ventricular dysfunction into symptomatic heart failure.

Receptor Binding (Indirect Mechanism):

Enalapril indirectly prevents Angiotensin II from binding to AT1 and AT2 receptors, thereby reducing vasoconstriction and improving cardiovascular function.

Dosage & Administration:

1. Adults: 1 tablet (10mg) once daily.
2. Special Populations: Dosage adjustments may be necessary in elderly individuals or those with renal impairments.

Contraindications:

Amotac should not be used in the following conditions:

1. Hypersensitivity to Enalapril Maleate or its excipients.
2. A history of angioedema associated with previous ACE inhibitor therapy.
3. Severe kidney impairment or certain other renal diseases.

Warnings & Precautions:

1. Monitor renal function and potassium levels during therapy.
2. Avoid combining this medication with potassium supplements, diuretics, or other drugs that may affect potassium levels.
3. Use with caution in individuals with a history of cardiovascular disease or compromised kidney function.

Drug Interactions:

1. Diuretics: May lead to excessive lowering of blood pressure.
2. Potassium supplements: May increase the risk of hyperkalemia.

Storage Information:

Store at room temperature (15°C – 25°C) in a light- and air-tight container.

Conclusion

1. Amotac 10mg is a safe and effective treatment for conditions such as hypertension, symptomatic heart failure, and asymptomatic left ventricular dysfunction.
2. The mechanism of action of Enalapril Maleate (the active ingredient) involves inhibiting ACE, which blocks the production of Angiotensin II, leading to vasodilation, reduced blood pressure, and improved heart and kidney health.
3. Its pharmacological effects include lowering blood pressure, improving cardiac function, and reducing kidney stress.
4. Enalapril acts by indirectly inhibiting AT1 and AT2 receptor binding, thereby reducing vasoconstriction and blood pressure.

Pharmacists and healthcare providers play a critical role in ensuring patient safety by educating them on side effects, proper dosage, and potential drug interactions. Adherence to proper dosing guidelines and regular monitoring can significantly improve therapeutic outcomes for patients on Amotac 10mg.