Amodip Tab 5mg 20’s-Potentail Overview

For the General Public

Medicine Name: Amodip
Brand: Amodip Tab 5mg 20’s
Active Ingredient(s): Amlodipine Besylate

1. Uses:
   This medicine is commonly used to treat high blood pressure (hypertension) and angina (chest pain due to reduced blood flow to the heart). It works by relaxing the blood vessels, making it easier for the heart to pump blood and reducing the strain on the heart.
2. Dosage:
   Take 1 tablet (5mg) once daily, with or without food. Always follow the instructions on the packaging or as prescribed by your doctor.
3. Possible Side Effects:
   Some common side effects may include: dizziness, flushing, headache, nausea, and swelling of the ankles or feet. If you experience anything unusual, contact your healthcare provider.
4. Important Information:
   • Do not take this medicine if you are allergic to amlodipine or any of the ingredients.
   • If you are pregnant, breastfeeding, or planning to become pregnant, consult your doctor before use.
   • Keep out of reach of children.
   • If you miss a dose, take it as soon as you remember unless it’s almost time for the next dose. Do not double the dose.

For Pharmacists

1. Medicine Name:
   Amodip
2. Brand:
   Amodip Tab 5mg 20’s
3. Active Ingredient(s):
   Amlodipine Besylate
4. Indications:
   Indicated for the management of hypertension (high blood pressure) and angina (chest pain due to reduced blood flow to the heart).
5. Pharmacodynamics:
   • Mechanism of Action:
     Amlodipine is a dihydropyridine calcium channel blocker. It inhibits the entry of calcium into vascular smooth muscle cells through L-type calcium channels, promoting vasodilation and reducing vascular resistance.
   • Pharmacological Effects:
     • Reduction in peripheral vascular resistance, leading to a drop in systemic blood pressure.
     • Relief from angina symptoms by decreasing myocardial oxygen demand.
     • Minimal Reflex Tachycardia: Unique compared to other dihydropyridine drugs.
   • Receptor Binding:
     Amlodipine binds selectively to L-type calcium channels, preventing calcium entry and thus causing vasodilation.
6. Pharmacokinetics:
   • Absorption: Well-absorbed after oral administration, with peak plasma concentrations occurring in 6-12 hours.
   • Distribution: 97% plasma protein binding, with a volume of distribution of 21 L.
   • Metabolism: Metabolized primarily in the liver via CYP3A4 pathways, with inactive metabolites formed.
   • Elimination: Excreted mainly in the urine.
   • Half-Life: 30-50 hours.
   • Bioavailability: ~60-80%.
7. Dosage and Administration:
   • Adults: Take 1 tablet (5mg) daily.
   • Pediatric: Not indicated for use in children under 6 years unless directed by a doctor.
   • Special Populations: Adjust dose in elderly or those with impaired liver or kidney function.
8. Contraindications:
   • Known hypersensitivity to amlodipine or any excipients in the formulation.
   • Severe aortic stenosis.
9. Warnings and Precautions:
   • Use with caution in patients with cardiovascular disease, renal impairment, or hepatic disease.
10. Drug Interactions:
    • May interact with drugs that inhibit CYP3A4, such as ketoconazole, diltiazem, or verapamil.
    • May interact with antihypertensive agents and diuretics leading to additive effects.
11. Adverse Reactions:
    • Common: Dizziness, headache, flushing, peripheral edema.
    • Serious: Anaphylaxis, severe hypotension, myocardial infarction.
12. Storage:
    Store at 15°C to 30°C, protected from light and air.
13. Packaging:
    Available in tablet form, in 5mg, 20’s pack sizes.

Conclusion

1. Mechanism of Action:
   • Amlodipine (active ingredient in Amodip) is a dihydropyridine calcium channel blocker.
   • It inhibits calcium ion entry into smooth muscle cells by targeting L-type calcium channels, leading to vasodilation.
2. Pharmacological Effects:
   • Reduced Peripheral Vascular Resistance: Leads to lower systemic blood pressure.
   • Angina Symptom Relief: Decreases myocardial oxygen demand.
   • Amlodipine causes minimal reflex tachycardia, unlike other dihydropyridines.
3. Receptor Binding:
   • Amlodipine binds specifically to L-type calcium channels, preventing calcium influx and promoting smooth muscle relaxation.
4. Clinical Implications:
   • Amodip (Amlodipine Besylate) has proven effective in managing hypertension and angina by improving blood flow and reducing the heart’s workload.
5. Patient & Pharmacist Responsibility:
   • Patients should adhere to the prescribed regimen and monitor for potential side effects.
   • Pharmacists and healthcare providers should educate patients about:
     • Drug interactions
     • Side effects
     • Safe medication storage and proper use.
6. Final Note:
   • Amodip offers a safe and effective treatment by leveraging its unique pharmacological properties, ensuring cardiovascular health when used correctly.