Alzilo Tab 1 Mg 10’s-Potential Overview: 

Brand Name: Alzilo

Active Ingredient(s): Donepezil Hydrochloride

For the General Public:

Uses: This medicine is commonly used to treat mild to moderate Alzheimer’s disease. It works by increasing the levels of acetylcholine in the brain, which helps improve memory and cognitive function.

• Dosage: Take 1 tablet once daily, preferably at bedtime. Always follow the instructions on the packaging or as prescribed by your doctor.

• Possible Side Effects: Some common side effects may include nausea, diarrhea, insomnia, muscle cramps, and fatigue. If you experience anything unusual, contact your healthcare provider.

o Common Side Effects: Nausea, diarrhea, insomnia, muscle cramps, fatigue, and loss of appetite.

o Serious (Less Common) Side Effects: Slow heart rate, fainting, severe gastrointestinal issues, or allergic reactions.

• Important Information:

o Dosage Instruction: Take 1 mg once daily, preferably at bedtime. Do not exceed the prescribed dose.

o Usage Instruction: Take this drug with or without food. Maintain a consistent schedule for better results.

o General Information: – Do not take this medicine if you are allergic to donepezil or have a history of severe liver problems.
– If you are pregnant, breastfeeding, or planning to become pregnant, consult your doctor before use.
– Keep out of reach of children.
– If you miss a dose, take it as soon as you remember unless it’s almost time for the next dose. Do not double the dose.

• Drug Interactions:

o Interactions with Other Medications: May interact with anticholinergics, NSAIDs, or other cholinergic drugs.

o Interactions with Food: No significant food interactions reported.

Regulatory Approval & Manufacturer: [Manufacturer Name].

Antidotes (If Overdosed or Misused by Patients): In cases of overdose, supportive care and symptomatic treatment are required. Administer atropine as an antidote if necessary and seek emergency medical attention.

For Pharmacists:

Medicine Name: Donepezil Hydrochloride
Brand: Alzilo
Active Ingredient(s): Donepezil Hydrochloride

Indications: Indicated for the treatment of mild to moderate Alzheimer’s disease.

Pharmacodynamics:

• Mechanism of Action: Donepezil acts as a reversible inhibitor of acetylcholinesterase, increasing acetylcholine levels in the brain, which enhances cholinergic function.

• Pharmacological Effects: Improves cognitive function, memory, and the ability to perform daily activities in patients with Alzheimer’s disease.

• Receptor Binding: Binds reversibly to acetylcholinesterase, preventing the breakdown of acetylcholine.

Pharmacokinetics:

• Absorption: Well absorbed with peak plasma concentrations reached within 3-4 hours.

• Distribution: Highly bound to plasma proteins (~96%).

• Metabolism: Metabolized in the liver via CYP450 enzymes (primarily CYP2D6 and CYP3A4).

• Elimination: Excreted in urine and feces as metabolites.

• Half-Life: Approximately 70 hours.

• Bioavailability: Oral bioavailability is about 100%.

• Time to Peak Concentration: 3-4 hours post-administration.

• Effect of Food: Food does not significantly affect absorption.

Dosage and Administration:

• Adults: 1 mg once daily, preferably at bedtime. Dosage may be increased based on clinical response.

• Pediatric: Not recommended for use in children.

• Special Populations: Adjust dose in hepatic impairment; use with caution in renal impairment.

Contraindications:

• Known hypersensitivity to donepezil or any excipients. • Contraindicated in patients with severe hepatic impairment.

Warnings and Precautions:

• Use with caution in patients with cardiovascular conditions, asthma, or gastrointestinal issues. • Monitor for signs of gastrointestinal bleeding, especially in patients taking NSAIDs.

Drug-Drug Interactions for Pharmacist:

• Potential interactions with NSAIDs, anticholinergic drugs, or CYP450 inhibitors/inducers. • Increased risk of side effects when combined with other cholinergic drugs.

Drug-Food Interactions for Pharmacist:

• No significant interactions with food.

Adverse Reactions:

• Common: Nausea, diarrhea, insomnia, muscle cramps, fatigue, and loss of appetite.

• Serious: Severe allergic reactions, slow heart rate, fainting, or gastrointestinal bleeding.

Therapeutic Effects:

• Enhances cholinergic function by increasing acetylcholine levels, improving memory and cognitive function.

Storage: Store at 15-30°C (59-86°F), in a light-resistant and airtight container.

Packaging: Available in tablet form, 1 mg strength, in blister packs of 10 tablets.

Clinical Considerations:

• Pregnancy Category: Category C. Use only if potential benefits justify the risks.

• Lactation Category: Not recommended. If treatment is necessary, discontinue breastfeeding.

• Pediatric Category: Safety and efficacy not established in children.

• Geriatric Category: Use with caution; monitor for side effects due to increased sensitivity.

• Adult Category: Standard dosing as per therapeutic response.

• Other Considerations: Monitor liver function and signs of gastrointestinal bleeding during treatment.

Conclusion: Alzilo (donepezil hydrochloride) is an effective treatment for mild to moderate Alzheimer’s disease, helping improve memory and daily functioning. Patients should adhere to proper dosing guidelines and report any unusual symptoms to their healthcare provider. Pharmacists should counsel patients on potential drug interactions, correct usage, and the importance of regular monitoring. Proper storage and disposal of the medication are essential to ensure its safety and effectiveness.