Alzilo Tab 0.5 Mg 10’s-Potential Overview:

Brand Name: Alzilo
Generic Name: Donepezil
Active Ingredient(s): Donepezil Hydrochloride

For the General Public:

Uses:
This medicine is commonly used to treat Alzheimer’s disease. It works by improving the function of nerve cells in the brain by preventing the breakdown of a chemical called acetylcholine.

• Dosage:
Take one tablet daily, preferably at bedtime, with or without food. Always follow the instructions on the packaging or as prescribed by your doctor.

• Possible Side Effects:
Some common side effects may include nausea, diarrhea, insomnia, or muscle cramps. If you experience anything unusual, contact your healthcare provider.

• Common Side Effects:
  • Gastrointestinal issues such as nausea or diarrhea
  • Fatigue or dizziness
• Serious (Less Common) Side Effects:
  • Severe allergic reactions
  • Irregular heartbeat

• Important Information:

• Dosage Instruction:
  Take one tablet daily at bedtime unless otherwise directed by your healthcare provider.
• Usage Instruction:
  Can be taken with or without food. Do not crush or chew the tablet.
• General Information:
  • Do not take this medicine if you are allergic to Donepezil or any of its ingredients.
  • If you are pregnant, breastfeeding, or planning to become pregnant, consult your doctor before use.
  • Keep out of reach of children.
  • If you miss a dose, take it as soon as you remember unless it’s almost time for the next dose. Do not double the dose.

• Drug Interactions:

• Interactions with Other Medications:
  May interact with anticholinergic drugs, NSAIDs, and certain heart medications.
• Interactions with Food:
  No significant food interactions are known.

Regulatory Approval & Manufacturer:
Approved for the treatment of Alzheimer’s disease by relevant regulatory bodies.

Antidotes:
In case of overdose, supportive measures and symptomatic treatment are recommended. Contact emergency medical services immediately.

For Pharmacists:

Medicine Name: Alzilo Tab 0.5 Mg
Brand: Alzilo
Active Ingredient(s): Donepezil Hydrochloride

Indications:
Indicated for the management of mild to moderate Alzheimer’s disease.

Pharmacodynamics:
• Mechanism of Action:
Donepezil acts as a reversible inhibitor of acetylcholinesterase, thereby increasing acetylcholine levels in the brain and improving cognitive function.

• Pharmacological Effects:
Enhances neurotransmission and cognitive function in Alzheimer’s patients.

• Receptor Binding:
Specifically binds to acetylcholinesterase enzymes.

Pharmacokinetics:
• Absorption:
Well-absorbed orally; peak plasma concentration occurs within 3-4 hours after administration.

• Distribution:
High plasma protein binding (~95%); widely distributed in tissues.

• Metabolism:
Metabolized in the liver via CYP enzymes, primarily CYP2D6 and CYP3A4.

• Elimination:
Excreted through urine and feces; clearance rates may vary.

• Half-Life:
Approximately 70 hours, allowing for once-daily dosing.

• Bioavailability:
High oral bioavailability (~100%).

• Time to Peak Concentration:
3-4 hours post-dose.

• Effect of Food:
Food does not significantly affect absorption.

Dosage and Administration:
• Adults:
One tablet (0.5 mg) daily at bedtime.

• Pediatric:
Not recommended for use in children.

• Special Populations:
Use with caution in patients with hepatic or renal impairment.

Contraindications:
• Known hypersensitivity to Donepezil or its excipients.
• Contraindicated in patients with severe liver impairment.

Warnings and Precautions:
• Use with caution in patients with cardiovascular conditions or gastrointestinal disorders.
• Monitor for potential adverse effects such as bradycardia or GI bleeding.

Drug-Drug Interactions for Pharmacist:
• Potential interactions with anticholinergic agents, NSAIDs, and CYP enzyme inhibitors.

Drug-Food Interactions for Pharmacist:
• No significant food interactions.

Adverse Reactions:
• Common:

• Nausea, diarrhea, and insomnia. • Serious:
• Bradycardia, syncope, or severe allergic reactions.

Therapeutic Effects:
• Improves cognitive function and memory in patients with Alzheimer’s disease.

Storage:
Store at 15-30°C, in a light-resistant container.

Packaging:
Available in blister packs containing 10 tablets.

Clinical Considerations:
• Pregnancy Category:
Use only if the potential benefit justifies the risk to the fetus.

• Lactation Category:
Not recommended during breastfeeding.

• Pediatric Category:
Not indicated for pediatric use.

• Geriatric Category:
Generally well-tolerated but requires monitoring for side effects.

• Other Considerations:
Adjust dose cautiously in hepatic or renal impairment.

Conclusion:
Alzilo Tab 0.5 Mg is an effective treatment for mild to moderate Alzheimer’s disease. When used as prescribed, it can improve cognitive function and quality of life. Patients and caregivers should adhere to the prescribed dosage and monitor for side effects. Pharmacists should counsel patients on potential drug interactions and the importance of adherence to therapy.