Brand Name: Agolix
Generic Name: Gatifloxacin
Active Ingredient(s): Gatifloxacin 400 mg

For the General Public:

Uses:
Agolix is used to treat bacterial infections, including respiratory tract infections, urinary tract infections, and skin infections. It works by stopping the growth of bacteria.

Dosage:

• Adults: Take one 400 mg tablet once daily, with or without food, or as prescribed by your doctor.
• Children: Not recommended unless specifically prescribed by a healthcare provider.

Possible Side Effects:

• Common Side Effects: Nausea, diarrhea, headache, dizziness, or abdominal pain.
• Serious (Less Common) Side Effects: Severe allergic reactions, tendon rupture, QT prolongation, or liver dysfunction.

Important Information:

• Dosage Instruction: Swallow the tablet whole with a glass of water.
• Usage Instruction: Take at the same time each day to maintain consistent drug levels in your body.
• General Information:
  • Do not take if allergic to gatifloxacin or other fluoroquinolones.
  • Avoid direct sunlight or UV exposure while on this medication as it may cause photosensitivity.

Drug Interactions:

• Interactions with Other Medications:
  • Avoid taking with antacids, calcium supplements, or iron products as they may interfere with absorption.
• Interactions with Food:
  • Dairy products may reduce drug absorption; take separately if possible.

Regulatory Approval & Manufacturer:
Approved by [regulatory body], manufactured by [manufacturer name].

Antidotes (If Overdose or Misuse by Patients):
Supportive care, including maintaining hydration and monitoring kidney function.

For Pharmacists:

Medicine Name: Agolix
Brand: Agolix
Active Ingredient(s): Gatifloxacin 400 mg

Indications:
Agolix is indicated for:

• Respiratory tract infections (e.g., bronchitis, sinusitis).
• Urinary tract infections.
• Skin and soft tissue infections.

Pharmacodynamics:

• Mechanism of Action:
  Gatifloxacin is a fluoroquinolone antibiotic that inhibits bacterial DNA gyrase and topoisomerase IV, enzymes essential for bacterial DNA replication and repair.
• Pharmacological Effects:
  • Bactericidal activity against a broad range of Gram-positive and Gram-negative bacteria.
• Receptor Binding:
  Gatifloxacin binds to bacterial DNA gyrase and topoisomerase IV with high affinity, preventing the unwinding of bacterial DNA necessary for replication.

Pharmacokinetics:

• Absorption: Rapidly absorbed after oral administration, with peak plasma levels reached in 1-2 hours.
• Distribution: Widely distributed in body tissues; moderate plasma protein binding (~20%).
• Metabolism: Metabolized minimally in the liver.
• Elimination: Excreted primarily unchanged in the urine.
• Half-Life: Approximately 7 to 14 hours.
• Bioavailability: Nearly 96% after oral administration.
• Effect of Food: Food has minimal effect on absorption; may be taken with or without meals.

Dosage and Administration:

• Adults: 400 mg once daily for 5-10 days, depending on infection type and severity.
• Elderly: No specific dose adjustment required, but monitor kidney function.
• Renal Impairment: Dosage adjustment may be needed.

Contraindications:

• Known hypersensitivity to gatifloxacin or other fluoroquinolones.
• Patients with a history of tendon disorders related to fluoroquinolone use.

Warnings and Precautions:

• Use with caution in patients with a history of seizures, QT prolongation, or electrolyte imbalance.
• Monitor blood glucose levels in diabetic patients as gatifloxacin may cause dysglycemia.

Drug-Drug Interactions:

• Concurrent use with antiarrhythmics or other QT-prolonging drugs may increase the risk of arrhythmias.
• Avoid simultaneous administration with magnesium/aluminum antacids, sucralfate, or multivitamins containing iron or zinc.

Drug-Food Interactions:

• Dairy products may reduce absorption; take separately if needed.

Adverse Reactions:

• Common: Nausea, headache, dizziness, diarrhea.
• Serious: Tendon rupture, severe hypersensitivity reactions, QT prolongation, hypoglycemia, or hyperglycemia.

Therapeutic Effects:

• Provides rapid bacterial eradication, reducing symptoms of infection and promoting recovery.

Storage:
Store at room temperature (15°C to 30°C), away from direct sunlight and moisture.

Packaging:
Available in tablet form, typically in blister packs of 10 tablets.

Clinical Considerations:

• Pregnancy Category: C (Use only if clearly needed).
• Lactation Category: Use with caution; not recommended during breastfeeding without consulting a physician.
• Pediatric Category: Not recommended for children under 18 years due to risk of musculoskeletal disorders.
• Geriatric Category: Monitor for renal function and QT prolongation.

Conclusion:

Agolix 400 mg Tab is a potent fluoroquinolone antibiotic effective against a variety of bacterial infections. It offers convenient once-daily dosing but requires caution in patients with a history of tendon issues or QT prolongation. Proper adherence to dosage instructions and awareness of potential side effects ensure optimal therapeutic outcomes. Pharmacists should educate patients about avoiding antacids and dairy products around dosing times and the importance of completing the full course of therapy.