Aerokast Tab 10 Mg 2×7’s-Potential Overview:

Brand Name: Aerokast
Generic Name: Montelukast Sodium
Active Ingredient(s): Montelukast 10 mg

For the General Public:

Uses:
Aerokast is used to:

• Prevent and manage chronic asthma symptoms, such as wheezing and shortness of breath.
• Relieve symptoms of allergic rhinitis (seasonal or perennial), such as sneezing, runny nose, and nasal congestion.
• Prevent exercise-induced bronchoconstriction (difficulty breathing during or after physical activity).

Dosage:

• Adults and Adolescents (15 years and older): One tablet (10 mg) daily in the evening.
• Can be taken with or without food.

Possible Side Effects:

• Common Side Effects: Headache, abdominal pain, fatigue, nausea, or dizziness.
• Serious (Less Common) Side Effects:
  • Mood or behavioral changes, such as anxiety, agitation, or depression.
  • Severe allergic reactions (rash, swelling, or difficulty breathing).

Important Information:

• Dosage Instruction: Follow the prescribed dosage. Do not double the dose if you miss one.
• Usage Instruction: Swallow the tablet whole with water.
• General Information:
  • Not intended for relief of acute asthma attacks; use a rescue inhaler for immediate relief.
  • Inform your doctor if you are pregnant, breastfeeding, or have liver issues.

Drug Interactions:

• Interactions with Other Medications: Medications like rifampin or phenytoin may reduce the effectiveness of montelukast.
• Interactions with Food: No significant food interactions reported.

Regulatory Approval & Manufacturer:
Approved by [regulatory authority], manufactured by [manufacturer].

Antidotes (If Overdose or Misuse by Patients):
No specific antidote; provide symptomatic and supportive care.

For Pharmacists:

Medicine Name: Aerokast
Brand: Aerokast
Active Ingredient(s): Montelukast Sodium 10 mg

Indications:

• Long-term management of asthma in adults and adolescents.
• Relief from symptoms of seasonal and perennial allergic rhinitis.
• Prevention of exercise-induced bronchoconstriction.

Pharmacodynamics:

• Mechanism of Action:
  Montelukast is a leukotriene receptor antagonist (LTRA) that blocks cysteinyl leukotriene (CysLT1) receptors in the airways and other pro-inflammatory cells.
• Pharmacological Effects:
  • Reduces inflammation and bronchial hyperresponsiveness.
  • Alleviates symptoms of allergic rhinitis by blocking leukotrienes.
• Receptor Binding:
  Selectively binds to CysLT1 receptors, inhibiting leukotriene activity and preventing airway inflammation and bronchoconstriction.

Pharmacokinetics:

• Absorption: Rapidly absorbed; peak plasma levels reached in 2-4 hours.
• Distribution: Highly bound to plasma proteins (~99%).
• Metabolism: Extensively metabolized in the liver via CYP3A4, CYP2C8, and CYP2C9 enzymes.
• Elimination: Excreted primarily in bile.
• Half-Life: 2.7 to 5.5 hours.
• Effect of Food: Food does not significantly affect absorption or efficacy.

Dosage and Administration:

• Adults and Adolescents (15 years and older): 10 mg once daily in the evening.
• Special Populations:
  • Elderly: No dosage adjustment required.
  • Hepatic Impairment: Use with caution and monitor liver function.

Contraindications:

• Hypersensitivity to montelukast or any excipients in the formulation.

Warnings and Precautions:

• Monitor for neuropsychiatric symptoms, such as mood changes or suicidal thoughts.
• Not suitable for acute asthma management; a short-acting bronchodilator is required for immediate relief.

Drug-Drug Interactions:

• CYP3A4 inducers like rifampin and phenytoin may reduce plasma levels of montelukast.

Drug-Food Interactions:

• No significant interactions reported.

Adverse Reactions:

• Common: Headache, abdominal pain, fatigue, or dizziness.
• Serious: Neuropsychiatric symptoms, severe allergic reactions.

Therapeutic Effects:

• Reduces airway inflammation and bronchoconstriction, providing effective symptom relief in asthma and allergic rhinitis.

Storage:
Store at 15-30°C in a dry place, away from moisture and direct sunlight.

Packaging:
Available as tablets in blister packs of 14 tablets (2×7’s).

Clinical Considerations:

• Pregnancy Category: B (use if benefits outweigh risks).
• Lactation Category: Limited data; consult a healthcare provider.
• Pediatric Use: Not recommended for children under 15 years.

Conclusion:

Aerokast Tab 10 mg is an effective and convenient treatment for managing asthma and allergic rhinitis in adults and adolescents. With once-daily dosing, it provides long-term symptom control and improves quality of life. Patients should be informed about proper usage and the importance of a rescue inhaler for acute symptoms. Pharmacists should monitor for drug interactions and educate patients on adherence to the prescribed regimen.