Aerius Tab 10 Mg 20’s-Potential Overview:

Brand Name: Aerius
Generic Name: Desloratadine
Active Ingredient(s): Desloratadine 10 mg

For the General Public:

Uses:
Aerius is an antihistamine used to:

• Relieve allergy symptoms such as sneezing, runny nose, itchy or watery eyes, and nasal congestion associated with seasonal or perennial allergic rhinitis.
• Treat chronic idiopathic urticaria (hives) by reducing itching and the size of hives.

Dosage:

• Adults and Adolescents (12 years and older): One tablet (10 mg) once daily.
• Can be taken with or without food.

Possible Side Effects:

• Common Side Effects: Headache, dry mouth, fatigue, or drowsiness.
• Serious (Less Common) Side Effects:
  • Severe allergic reactions (swelling, rash, difficulty breathing).
  • Rapid or irregular heartbeat.

Important Information:

• Dosage Instruction: Take the prescribed dose at the same time every day. Do not exceed the recommended dosage.
• Usage Instruction: Swallow the tablet whole with water.
• General Information:
  • Avoid use if you are allergic to desloratadine or loratadine.
  • Inform your doctor if you are pregnant, breastfeeding, or have kidney or liver problems.

Drug Interactions:

• Interactions with Other Medications: Inform your doctor if you are taking any other antihistamines or medications for colds or allergies.
• Interactions with Food: No significant food interactions reported.

Regulatory Approval & Manufacturer:
Approved by [regulatory authority], manufactured by [manufacturer].

Antidotes (If Overdose or Misuse by Patients):
There is no specific antidote; provide symptomatic and supportive care.

For Pharmacists:

Medicine Name: Aerius
Brand: Aerius
Active Ingredient(s): Desloratadine 10 mg

Indications:

• Relief of symptoms associated with allergic rhinitis (seasonal and perennial).
• Symptomatic treatment of chronic idiopathic urticaria.

Pharmacodynamics:

• Mechanism of Action:
  Desloratadine is a selective histamine H1-receptor antagonist that blocks histamine, a substance responsible for allergic symptoms, without causing significant drowsiness.
• Pharmacological Effects:
  • Reduces nasal and ocular symptoms of allergic rhinitis.
  • Alleviates itching and hives in urticaria.
• Receptor Binding:
  Strongly binds to H1 receptors, inhibiting histamine-mediated effects, including vasodilation and increased vascular permeability.

Pharmacokinetics:

• Absorption: Rapidly absorbed; peak plasma concentration achieved within 3 hours.
• Distribution: Moderately bound to plasma proteins (~85%).
• Metabolism: Extensively metabolized in the liver; active metabolite is not clinically significant.
• Elimination: Primarily excreted in urine and feces as metabolites.
• Half-Life: Approximately 27 hours.
• Effect of Food: Food does not significantly affect absorption.

Dosage and Administration:

• Adults and Adolescents (12 years and older): 10 mg once daily.
• Special Populations:
  • Use with caution in patients with severe renal or hepatic impairment.

Contraindications:

• Hypersensitivity to desloratadine, loratadine, or any of the excipients in the formulation.

Warnings and Precautions:

• Use with caution in patients with a history of cardiovascular disease.
• Avoid use if there is a known allergy to similar antihistamines.

Drug-Drug Interactions:

• Avoid concurrent use with other sedative antihistamines or CNS depressants, which may increase drowsiness.

Drug-Food Interactions:

• No significant food interactions; however, alcohol consumption should be avoided to prevent enhanced sedative effects.

Adverse Reactions:

• Common: Headache, dry mouth, fatigue, or nausea.
• Serious: Severe allergic reactions, tachycardia, or palpitations.

Therapeutic Effects:

• Provides effective relief from allergic rhinitis and chronic urticaria symptoms.

Storage:
Store below 25°C in a dry place, away from direct light and moisture.

Packaging:
Available as tablets in blister packs of 20 (2×10’s).

Clinical Considerations:

• Pregnancy Category: C (use only if benefits outweigh risks).
• Lactation Category: Use with caution; small amounts may pass into breast milk.
• Pediatric Use: Not recommended for children under 12 years.

Conclusion:

Aerius Tab 10 mg is an effective antihistamine for treating allergic rhinitis and chronic urticaria. Its once-daily dosing provides convenience and long-lasting relief. Patients should be informed about potential side effects and instructed to avoid alcohol. Pharmacists should ensure that patients are aware of proper storage and usage instructions.