Adytum Tab 2.5 Mg 28’s-Potential Overview:

Brand Name: Adytum
Generic Name: Tadalafil
Active Ingredient(s): Tadalafil 2.5 mg

For the General Public:

Uses:
Adytum is used to:

• Treat erectile dysfunction (ED) by improving blood flow to the penis, helping to achieve and maintain an erection during sexual activity.
• Manage the symptoms of benign prostatic hyperplasia (BPH), such as difficulty in urination.

Dosage:

• For Erectile Dysfunction (ED): One tablet (2.5 mg) taken once daily, at the same time each day.
• For Benign Prostatic Hyperplasia (BPH): One tablet (2.5 mg) once daily.
• Can be taken with or without food.

Possible Side Effects:

• Common Side Effects: Headache, flushing, indigestion, back pain, muscle aches, nasal congestion, or dizziness.
• Serious (Less Common) Side Effects:
  • Sudden vision or hearing loss.
  • Prolonged or painful erection lasting more than 4 hours (priapism).
  • Severe allergic reactions (swelling, difficulty breathing).

Important Information:

• Dosage Instruction: Take exactly as prescribed. Do not exceed the recommended dose.
• Usage Instruction: Swallow the tablet whole with water.
• General Information:
  • Avoid use if you are allergic to tadalafil or taking nitrates for chest pain.
  • Inform your doctor if you have a history of heart problems, low blood pressure, or liver or kidney disease.

Drug Interactions:

• Interactions with Other Medications:
  • Avoid combining with nitrates (e.g., nitroglycerin) or alpha-blockers, as it may cause a dangerous drop in blood pressure.
  • Interactions with medications like ketoconazole or ritonavir may increase tadalafil levels.
• Interactions with Food: Avoid excessive alcohol consumption, which may increase the risk of side effects like dizziness.

Regulatory Approval & Manufacturer:
Approved by [regulatory authority], manufactured by [manufacturer].

Antidotes (If Overdose or Misuse by Patients):
No specific antidote; provide symptomatic and supportive care.

For Pharmacists:

Medicine Name: Adytum
Brand: Adytum
Active Ingredient(s): Tadalafil 2.5 mg

Indications:

• Erectile Dysfunction (ED).
• Benign Prostatic Hyperplasia (BPH).

Pharmacodynamics:

• Mechanism of Action:
  Tadalafil is a phosphodiesterase type 5 (PDE5) inhibitor. It enhances the effects of nitric oxide by inhibiting PDE5, leading to increased levels of cyclic guanosine monophosphate (cGMP). This results in relaxation of smooth muscle and improved blood flow to specific areas, such as the penis and prostate.
• Pharmacological Effects:
  • Improves erectile function in ED by increasing blood flow to the penis.
  • Relieves BPH symptoms by relaxing smooth muscles in the prostate and bladder.
• Receptor Binding:
  High specificity for PDE5 receptors in vascular smooth muscle, leading to localized vasodilation and improved therapeutic outcomes.

Pharmacokinetics:

• Absorption: Rapidly absorbed; peak plasma concentration reached within 2 hours.
• Distribution: Highly protein-bound (~94%).
• Metabolism: Metabolized in the liver primarily by CYP3A4 enzymes.
• Elimination: Excreted mostly in feces (~61%) and urine (~36%).
• Half-Life: Approximately 17.5 hours.
• Effect of Food: No significant effect on absorption or efficacy.

Dosage and Administration:

• Adults:
  • ED/BPH: 2.5 mg once daily.
• Special Populations:
  • Dose adjustment may be required in severe renal or hepatic impairment.

Contraindications:

• Concurrent use with nitrates or guanylate cyclase stimulators.
• Hypersensitivity to tadalafil or any excipients.

Warnings and Precautions:

• Use cautiously in patients with cardiovascular disease or a predisposition to priapism.
• Avoid in patients with severe hepatic impairment.

Drug-Drug Interactions:

• Significant interactions with nitrates, alpha-blockers, and potent CYP3A4 inhibitors like ketoconazole and ritonavir.

Drug-Food Interactions:

• Excessive alcohol may enhance side effects like dizziness or headache.

Adverse Reactions:

• Common: Headache, flushing, dyspepsia, nasal congestion.
• Serious: Vision or hearing loss, priapism, severe allergic reactions.

Therapeutic Effects:

• Enhances erectile function and relieves urinary symptoms in BPH.

Storage:
Store at 15-30°C in a dry place, protected from light and moisture.

Packaging:
Available as tablets in blister packs of 28 tablets.

Clinical Considerations:

• Pregnancy Category: Not indicated for use in women.
• Lactation Category: Not indicated for use in women.
• Pediatric Use: Safety and efficacy not established in individuals under 18 years.

Conclusion:

Adytum Tab 2.5 mg is an effective treatment for erectile dysfunction and benign prostatic hyperplasia. With once-daily dosing, it offers convenience and consistent therapeutic effects. Patients should adhere to prescribed instructions and report any unusual symptoms to their healthcare provider. Pharmacists should counsel patients on proper usage, potential drug interactions, and precautions.