Advantec Tab 2×14’s-Potential Overview:

Brand Name: Advantec
Generic Name: Pantoprazole
Active Ingredient(s): Pantoprazole Sodium Sesquihydrate 40 mg

For the General Public:

Uses:
Advantec is used to:

• Treat gastroesophageal reflux disease (GERD) and associated symptoms such as heartburn.
• Manage conditions involving excessive stomach acid production, such as Zollinger-Ellison syndrome.
• Promote healing of erosive esophagitis.
• Provide relief from stomach ulcers caused by nonsteroidal anti-inflammatory drugs (NSAIDs).

Dosage:

• For GERD/Erosive Esophagitis: Take one tablet (40 mg) once daily for 4-8 weeks.
• For Zollinger-Ellison Syndrome: Dosage varies; consult your doctor.
• Can be taken with or without food.

Possible Side Effects:

• Common Side Effects: Headache, diarrhea, nausea, abdominal pain, dizziness, or flatulence.
• Serious (Less Common) Side Effects:
  • Severe allergic reactions (rash, swelling, difficulty breathing).
  • Low magnesium levels (muscle spasms, irregular heartbeat).
  • Persistent or severe diarrhea (may indicate Clostridium difficile infection).

Important Information:

• Dosage Instruction: Do not exceed the recommended dose. Follow your doctor’s instructions.
• Usage Instruction: Swallow the tablet whole with water; do not crush or chew.
• General Information:
  • Avoid use if you are allergic to pantoprazole or other proton pump inhibitors (PPIs).
  • Inform your doctor if you have liver problems or are taking other medications.
  • Prolonged use may increase the risk of bone fractures or vitamin B12 deficiency.

Drug Interactions:

• Interactions with Other Medications:
  • May reduce the effectiveness of drugs requiring acidic stomach pH (e.g., ketoconazole, atazanavir).
  • Can interfere with warfarin or clopidogrel metabolism.
• Interactions with Food: No significant interactions; can be taken with or without meals.

Regulatory Approval & Manufacturer:
Approved by [regulatory authority], manufactured by [manufacturer].

Antidotes (If Overdose or Misuse by Patients):
Supportive treatment; seek medical attention immediately.

For Pharmacists:

Medicine Name: Advantec
Brand: Advantec
Active Ingredient(s): Pantoprazole Sodium Sesquihydrate 40 mg

Indications:

• Gastroesophageal reflux disease (GERD).
• Zollinger-Ellison syndrome.
• Erosive esophagitis.
• Prevention of NSAID-induced gastric ulcers.

Pharmacodynamics:

• Mechanism of Action:
  Pantoprazole is a proton pump inhibitor (PPI). It irreversibly binds to the H+/K+-ATPase enzyme in gastric parietal cells, inhibiting the final step of acid production, leading to a reduction in gastric acidity.
• Pharmacological Effects:
  • Suppresses gastric acid secretion.
  • Promotes healing of gastric and duodenal ulcers.
  • Reduces acid-related symptoms like heartburn.
• Receptor Binding:
  Binds specifically to the H+/K+-ATPase enzyme at the parietal cell surface, with high selectivity for the proton pump.

Pharmacokinetics:

• Absorption: Rapidly absorbed; peak plasma concentration achieved in 2-3 hours.
• Distribution: Protein binding ~98%.
• Metabolism: Extensively metabolized in the liver via the CYP2C19 pathway.
• Elimination: Excreted primarily in urine (~80%) and feces (~20%).
• Half-Life: Approximately 1 hour.
• Effect of Food: Food delays absorption but does not affect overall bioavailability.

Dosage and Administration:

• Adults: One tablet (40 mg) once daily.
• Special Populations:
  • Dose adjustment may be required in severe liver impairment.

Contraindications:

• Hypersensitivity to pantoprazole or other PPIs.

Warnings and Precautions:

• Use cautiously in patients with liver disease.
• Long-term use may increase the risk of bone fractures and vitamin B12 deficiency.

Drug-Drug Interactions:

• Reduced effectiveness of drugs requiring acidic stomach pH (e.g., ketoconazole, atazanavir).
• May potentiate warfarin effects, requiring monitoring of INR.

Drug-Food Interactions:

• Minimal impact of food on efficacy.

Adverse Reactions:

• Common: Headache, diarrhea, nausea, abdominal pain, dizziness.
• Serious: Severe allergic reactions, hypomagnesemia, Clostridium difficile-associated diarrhea.

Therapeutic Effects:

• Reduces stomach acid secretion.
• Relieves GERD symptoms and promotes mucosal healing.

Storage:
Store at 15-30°C in a dry place, away from light and moisture.

Packaging:
Available as blister packs containing 28 tablets (2 strips of 14 tablets each).

Clinical Considerations:

• Pregnancy Category: Consult a doctor; use only if necessary.
• Lactation Category: Limited data available; use with caution.
• Pediatric Use: Safety and efficacy not established in children under 12 years.

Conclusion:

Advantec Tab 40 mg is a highly effective treatment for GERD and acid-related conditions. Its once-daily dosing offers convenience and consistent symptom relief. Patients should adhere to prescribed guidelines and consult their healthcare provider for any concerns or unusual side effects. Pharmacists should counsel patients on proper usage and potential interactions.