Adronil Tab 150 mg 1’s-Potential Overview:

Brand Name: Adronil
Generic Name: Aripiprazole
Active Ingredient(s): Aripiprazole 150 mg

For the General Public:

Uses:
Adronil is used to:

• Manage symptoms of schizophrenia and other psychotic disorders.
• Treat bipolar disorder, helping to stabilize mood episodes.
• Aid in the treatment of major depressive disorder.

Dosage:

• For Schizophrenia/Bipolar Disorder: 150 mg once a month as an intramuscular injection.
• For Major Depressive Disorder: 150 mg once a month as intramuscular injection.
• Always follow the instructions provided by your healthcare provider.

Possible Side Effects:

• Common Side Effects: Drowsiness, headache, nausea, weight gain, dizziness.
• Serious (Less Common) Side Effects:
  • Extrapyramidal symptoms (tremors, muscle stiffness).
  • Akathisia (restlessness).
  • Tardive dyskinesia.
  • Increased risk of suicidal thoughts in some patients.

Important Information:

• Dosage Instruction: Use exactly as prescribed by your healthcare provider.
• Usage Instruction: For intramuscular use only; not for oral administration.
• General Information:
  • Avoid if allergic to aripiprazole or any of its ingredients.
  • Inform your doctor if you have a history of heart conditions, liver or kidney issues, or any other psychiatric disorders.
  • Regular monitoring is advised for effectiveness and side effects.

Drug Interactions:

• Interactions with Other Medications:
  • May interact with medications affecting dopamine levels (e.g., other antipsychotics, certain antidepressants).
  • Caution is advised with medications that impact the central nervous system.
• Interactions with Food: No significant food interactions.

Regulatory Approval & Manufacturer:
Approved by [regulatory authority], manufactured by [manufacturer].

Antidotes (If Overdose or Misuse by Patients):

• Supportive care and monitoring; symptomatic treatment for extrapyramidal symptoms and other severe reactions. Seek immediate medical attention if overdose is suspected.

For Pharmacists:

Medicine Name: Adronil
Brand: Adronil
Active Ingredient(s): Aripiprazole 150 mg

Indications:

• Schizophrenia.
• Bipolar disorder.
• Major depressive disorder (as adjunctive treatment).

Pharmacodynamics:

• Mechanism of Action:
  Aripiprazole is a partial agonist at dopamine D2 receptors and serotonin 5-HT1A receptors, with antagonistic activity at serotonin 5-HT2A receptors. It modulates dopamine and serotonin neurotransmission, stabilizing mood and alleviating psychotic symptoms.
• Pharmacological Effects:
  • Improves psychotic symptoms.
  • Stabilizes mood episodes in bipolar disorder.
  • Reduces depressive symptoms when used adjunctively.
• Receptor Binding:
  High affinity for dopamine D2 and serotonin 5-HT2A receptors, providing balanced effects on both dopamine and serotonin pathways.

Pharmacokinetics:

• Absorption: Well absorbed following intramuscular administration.
• Distribution: High volume of distribution (~9-12 L/kg).
• Metabolism: Metabolized extensively in the liver via CYP3A4 and CYP2D6.
• Elimination: Primarily excreted through urine and feces.
• Half-Life: Approximately 75 hours.
• Effect of Food: Minimal impact of food on bioavailability.

Dosage and Administration:

• Adults:
  • 150 mg once a month intramuscularly for maintenance therapy.
• Special Populations:
  • Monitor carefully in patients with hepatic or renal impairment.

Contraindications:

• Hypersensitivity to aripiprazole or any excipients.
• History of neuroleptic malignant syndrome (NMS) or severe tardive dyskinesia.

Warnings and Precautions:

• Use with caution in patients with:
  • Cardiovascular conditions.
  • Liver or kidney dysfunction.
  • Diabetes or risk factors for metabolic syndrome.
• Monitor for extrapyramidal symptoms and metabolic effects regularly.

Drug-Drug Interactions:

• Enhanced risk of side effects with CYP3A4 inhibitors and inducers.
• Caution with drugs affecting dopamine receptor activity.

Drug-Food Interactions:

• Minimal interaction with food.

Adverse Reactions:

• Common: Drowsiness, weight gain, headache, akathisia.
• Serious: Extrapyramidal symptoms, neuroleptic malignant syndrome, increased risk of suicidal thoughts.

Therapeutic Effects:

• Improves psychosis symptoms.
• Stabilizes mood disorders.

Storage:
Store at 15-30°C, protected from light and moisture.

Packaging:
Available as a 1 mL vial for intramuscular injection.

Clinical Considerations:

• Pregnancy Category: C (use only if the benefits outweigh the risks).
• Lactation Category: Use with caution; aripiprazole may pass into breast milk.
• Pediatric Use: Not approved for use in children under 18 years.
• Geriatric Use: Monitor for extrapyramidal symptoms and sedation.

Conclusion:

Adronil Tab 150 mg is an effective antipsychotic treatment for schizophrenia, bipolar disorder, and major depressive disorder (in adjunctive therapy). Regular monitoring of patients is crucial to manage side effects and ensure therapeutic efficacy. Pharmacists should counsel patients on proper usage, potential side effects, and drug interactions.