Adenuric 40 mg Tab 20’s-Potential Overview:

Brand Name: Adenuric
Generic Name: Febuxostat
Active Ingredient(s): Febuxostat 40 mg

For the General Public:

Uses:
Adenuric is used to:

• Manage hyperuricemia (high levels of uric acid) in patients with gout.
• Reduce the risk of gout flares and complications associated with elevated uric acid levels.

Dosage:

• For Gout Management: 40 mg once daily.
• Dosage may be adjusted by a healthcare provider depending on the patient’s response and uric acid levels.

Possible Side Effects:

• Common Side Effects: Nausea, headache, joint pain, elevated liver enzymes.
• Serious (Less Common) Side Effects:
  • Allergic reactions (rash, swelling).
  • Liver toxicity, severe kidney impairment.
  • Heart issues like arrhythmias.

Important Information:

• Dosage Instruction: Take exactly as prescribed by your doctor, preferably with or without food.
• Usage Instruction: Follow the prescribed dosage and do not double the dose.
• General Information:
  • Not recommended for use in patients with severe renal impairment.
  • Avoid alcohol and purine-rich foods as they may exacerbate gout symptoms.

Drug Interactions:

• Interactions with Other Medications:
  • Increased risk of interactions with azathioprine or mercaptopurine, requiring dose adjustments.
  • Caution with other drugs that affect the liver or kidneys.
• Interactions with Food:
  • Alcohol may increase uric acid levels and worsen gout symptoms.

Regulatory Approval & Manufacturer:
Approved by [regulatory authority], manufactured by [manufacturer].

Antidotes (If Overdose or Misuse by Patients):

• Supportive care for overdose; symptomatic treatment focusing on renal and liver function. Seek immediate medical attention if overdose occurs.

For Pharmacists:

Medicine Name: Adenuric
Brand: Adenuric
Active Ingredient(s): Febuxostat 40 mg

Indications:

• Treatment of hyperuricemia in patients with gout to reduce serum uric acid levels.
• Management of gout flares associated with elevated uric acid.

Pharmacodynamics:

• Mechanism of Action:
  Febuxostat inhibits xanthine oxidase, an enzyme involved in the conversion of xanthine to uric acid, thus reducing uric acid production.
• Pharmacological Effects:
  • Lowers serum uric acid levels.
  • Reduces the risk of gout flares.
• Receptor Binding:
  Selectively inhibits xanthine oxidase, a critical enzyme for uric acid synthesis.

Pharmacokinetics:

• Absorption: Rapid absorption with peak plasma concentration within 1 hour.
• Distribution: Extensively bound to plasma proteins (~99%).
• Metabolism: Metabolized in the liver through oxidation and glucuronidation.
• Elimination: Excreted primarily through urine, some via feces.
• Half-Life: Approximately 6-8 hours.
• Effect of Food: Food has minimal effect on the absorption of febuxostat.

Dosage and Administration:

• Adults:
  • 40 mg once daily, adjusted based on uric acid levels and clinical response.
• Special Populations:
  • Monitor liver and renal function in patients with compromised functions.

Contraindications:

• Hypersensitivity to febuxostat or any of its excipients.
• Severe renal impairment (CrCl <30 mL/min).

Warnings and Precautions:

• Use with caution in:
  • Patients with a history of cardiovascular disease.
  • Hepatic or renal impairment.
  • Elderly patients who may be more prone to adverse effects.

Drug-Drug Interactions:

• Increased risk of toxicity with azathioprine or mercaptopurine.
• Monitor closely when co-administered with other drugs that affect the liver or kidney functions.

Drug-Food Interactions:

• Alcohol and purine-rich foods may exacerbate gout symptoms and should be avoided.

Adverse Reactions:

• Common: Nausea, headache, gastrointestinal discomfort, rash.
• Serious: Liver toxicity, severe kidney impairment, allergic reactions.

Therapeutic Effects:

• Effectively reduces serum uric acid levels, lowering the risk of gout flares and complications.

Storage:
Store at 15-30°C, protected from light and moisture.

Packaging:
Available in blister packs of 20 tablets.

Clinical Considerations:

• Pregnancy Category: C (avoid use unless clearly necessary).
• Lactation Category: Caution advised.
• Pediatric Use: Not recommended for children.
• Geriatric Use: Monitor for adverse effects, particularly in the elderly with potential renal and hepatic impairments.

Conclusion:

Adenuric 40 mg Tab is a selective xanthine oxidase inhibitor that effectively manages hyperuricemia in patients with gout. It reduces uric acid levels and lowers the risk of gout flares and associated complications. Proper monitoring of renal and liver function is essential during treatment. Pharmacists should advise patients on proper use, potential side effects, and the importance of lifestyle modifications like avoiding alcohol and purine-rich foods.