Adalat LA Tab 30 mg 2×10’s-Potential Overview:

Brand Name: Adalat
Generic Name: Nifedipine
Active Ingredient(s): Nifedipine 30 mg

For the General Public:

Uses:
Adalat LA is used to:

• Manage hypertension (high blood pressure).
• Treat chronic stable angina (chest pain).
• Manage certain types of vascular disorders.

Dosage:

• Hypertension and Angina: 30 mg once daily.
• Dosage may be adjusted based on patient response.

Possible Side Effects:

• Common Side Effects: Dizziness, headache, flushing, nausea, palpitations.
• Serious (Less Common) Side Effects:
  • Severe hypotension (low blood pressure).
  • Peripheral edema (swelling of limbs).
  • Heart-related issues like arrhythmias.

Important Information:

• Dosage Instruction: Take exactly as prescribed, preferably at the same time each day.
• Usage Instruction: Can be taken with or without food.
• General Information:
  • Not recommended for patients with severe aortic stenosis or unstable angina.
  • Caution in patients with impaired liver function.

Drug Interactions:

• Interactions with Other Medications:
  • Increased risk of hypotension when combined with other antihypertensive medications.
  • Potential interaction with medications affecting heart rate or conduction.
• Interactions with Food:
  • Grapefruit juice may increase nifedipine levels, leading to enhanced side effects.

Regulatory Approval & Manufacturer:
Approved by [regulatory authority], manufactured by [manufacturer].

Antidotes (If Overdose or Misuse by Patients):

• In cases of overdose, supportive care including fluid management and vasopressors may be required. Seek immediate medical attention.

For Pharmacists:

Medicine Name: Adalat LA
Brand: Adalat
Active Ingredient(s): Nifedipine 30 mg

Indications:

• Treatment of hypertension.
• Chronic stable angina.
• Certain vascular disorders.

Pharmacodynamics:

• Mechanism of Action:
  Nifedipine is a calcium channel blocker that inhibits the influx of calcium ions into smooth muscle and myocardial cells, reducing vascular resistance and myocardial oxygen demand.
• Pharmacological Effects:
  • Relaxes arterial smooth muscle, leading to vasodilation and reduced blood pressure.
  • Reduces frequency and intensity of angina attacks.
• Receptor Binding:
  Binds selectively to L-type calcium channels in vascular smooth muscle and myocardial tissue.

Pharmacokinetics:

• Absorption: Rapidly absorbed, with peak plasma concentration within 30-60 minutes.
• Distribution: Extensive tissue distribution, with a high volume of distribution.
• Metabolism: Hepatic metabolism via the CYP3A4 pathway.
• Elimination: Primarily excreted via urine.
• Half-Life: Approximately 6-8 hours.
• Effect of Food: Food slows down the absorption of nifedipine, reducing peak plasma concentration.

Dosage and Administration:

• Adults:
  • 30 mg once daily, adjusted based on patient’s blood pressure and response.
• Special Populations:
  • Monitor closely in patients with hepatic impairment or older adults.

Contraindications:

• Severe hypotension, shock.
• Known hypersensitivity to nifedipine or its excipients.
• Unstable angina or acute myocardial infarction.

Warnings and Precautions:

• Use with caution in:
  • Patients with liver impairment or heart failure.
  • Patients at risk of hypotension.

Drug-Drug Interactions:

• Increased risk of hypotension when combined with other antihypertensive drugs.
• Grapefruit juice can increase nifedipine levels, potentially causing toxicity.

Drug-Food Interactions:

• Grapefruit juice can enhance nifedipine absorption and effects.

Adverse Reactions:

• Common: Dizziness, headache, flushing, peripheral edema.
• Serious: Severe hypotension, arrhythmias, peripheral swelling.

Therapeutic Effects:

• Effective in lowering blood pressure and relieving angina by relaxing vascular smooth muscle and reducing myocardial oxygen demand.

Storage:
Store at 15-30°C, protected from light and moisture.

Packaging:
Available in blister packs of 2×10 tablets.

Clinical Considerations:

• Pregnancy Category: C (use only if necessary).
• Lactation Category: Use with caution.
• Pediatric Use: Not recommended for children.
• Geriatric Use: Monitor closely for adverse effects in elderly patients.

Conclusion:

Adalat LA 30 mg Tab is an effective calcium channel blocker used primarily to manage hypertension and angina. Careful monitoring is required for patients at risk of hypotension, especially those with liver impairment or heart disease.