Actim Tab 2.5 mg 30’s-Potential Overview:

Brand Name: Actim
Generic Name: Bisoprolol Fumarate
Active Ingredient(s): Bisoprolol Fumarate 2.5 mg

For the General Public:

Uses:
Actim is commonly used to treat:

• High blood pressure (hypertension).
• Chronic stable angina (chest pain).
• Certain cases of heart failure.

It works by relaxing blood vessels and slowing the heart rate, which improves blood flow and reduces blood pressure.

Dosage:

• Typically, one tablet (2.5 mg) once daily, preferably in the morning.
• Your doctor may adjust the dosage depending on your condition.

Possible Side Effects:

• Common Side Effects:
  • Fatigue, dizziness, headache, and nausea.
  • Cold hands or feet.
• Serious (Less Common) Side Effects:
  • Shortness of breath, swelling in the legs, or severe bradycardia (slow heart rate).

Important Information:

• Dosage Instruction: Take as directed by your doctor. Do not stop the medication abruptly.
• Usage Instruction: Swallow the tablet whole with water, with or without food.
• General Information:
  • Avoid this medicine if allergic to bisoprolol or other beta-blockers.
  • Inform your doctor if you have asthma, severe heart conditions, or kidney/liver problems.
  • Consult your healthcare provider if pregnant or breastfeeding.

Drug Interactions:

• Interactions with Other Medications:
  • Avoid taking it with calcium channel blockers like verapamil or diltiazem without medical advice.
  • May interact with medications for diabetes, increasing the risk of hypoglycemia.
• Interactions with Food:
  • Alcohol can amplify side effects like dizziness or drowsiness.

Regulatory Approval & Manufacturer:
Approved by [regulatory authority], manufactured by [manufacturer].

Antidotes (If Overdose or Misuse):
Overdose can lead to severe bradycardia, hypotension, or heart block. Immediate medical attention is required. Supportive treatments may include atropine or glucagon.

For Pharmacists:

Medicine Name: Actim
Brand: Actim
Active Ingredient(s): Bisoprolol Fumarate 2.5 mg

Indications:

• Hypertension management.
• Treatment of chronic stable angina.
• Supportive therapy in heart failure.

Pharmacodynamics:

• Mechanism of Action:
  Bisoprolol selectively blocks beta-1 adrenergic receptors, decreasing heart rate, myocardial contractility, and cardiac output, which reduces blood pressure and myocardial oxygen demand.
• Pharmacological Effects:
  • Lowers blood pressure.
  • Reduces heart workload.
  • Improves exercise tolerance in angina patients.
• Receptor Binding:
  High selectivity for beta-1 adrenergic receptors in cardiac tissue, reducing adrenergic stimulation and achieving therapeutic effects.

Pharmacokinetics:

• Absorption: Well-absorbed orally, with bioavailability of approximately 90%.
• Distribution: Limited crossing of the blood-brain barrier.
• Metabolism: Partially metabolized in the liver.
• Elimination: Excreted equally in urine and feces.
• Half-Life: 10-12 hours.
• Effect of Food: Food has minimal impact on absorption.

Dosage and Administration:

• Adults: 2.5 mg once daily. May be increased as needed, up to a maximum of 20 mg/day.
• Pediatric: Not recommended.
• Special Populations:
  • Renal Impairment: Start with a lower dose; monitor renal function.
  • Hepatic Impairment: Adjust dose cautiously.

Contraindications:

• Hypersensitivity to bisoprolol or beta-blockers.
• Severe bradycardia, cardiogenic shock, or heart block.
• Untreated pheochromocytoma or severe asthma.

Warnings and Precautions:

• Use with caution in patients with diabetes, as bisoprolol may mask hypoglycemia symptoms.
• Abrupt discontinuation may cause rebound hypertension or angina.

Drug-Drug Interactions:

• Caution when combined with calcium channel blockers, antiarrhythmics, or other antihypertensive drugs.
• NSAIDs may reduce antihypertensive effects.

Drug-Food Interactions:

• Alcohol may enhance side effects like dizziness and drowsiness.

Adverse Reactions:

• Common: Fatigue, dizziness, nausea, headache.
• Serious: Severe bradycardia, heart failure, bronchospasm.

Therapeutic Effects:

• Reduces heart rate and blood pressure, relieving symptoms of hypertension and angina.

Storage:
Store at 15-30°C in a dry place, protected from light and moisture.

Packaging:
Blister pack containing 30 tablets.

Clinical Considerations:

• Pregnancy Category: C (Use only if benefits outweigh risks).
• Lactation: Excreted in breast milk; use with caution.
• Pediatric: Not recommended for children.
• Geriatric: Start with a lower dose and monitor closely.

Conclusion:

Actim Tab 2.5 mg is an effective beta-blocker for managing hypertension, angina, and heart failure. Its lower dosage makes it suitable for initiating treatment or for patients requiring a smaller dose. Adherence to prescribed guidelines and close monitoring are essential to maximize benefits and minimize risks. Always consult a healthcare professional for advice on potential side effects or concerns.