Actim Tab 10 mg 14’s-Potential Overview:

Brand Name: Actim
Generic Name: Bisoprolol Fumarate
Active Ingredient(s): Bisoprolol Fumarate 10 mg

For the General Public:

Uses:
Actim is commonly used to treat:

• High blood pressure (hypertension).
• Chronic stable angina (chest pain).
• Certain cases of heart failure.

It works by relaxing blood vessels and slowing the heart rate, improving blood flow and reducing blood pressure.

Dosage:

• Usually, one tablet (10 mg) once daily, preferably in the morning.
• Always follow your doctor’s instructions.

Possible Side Effects:

• Common Side Effects:
  • Dizziness, fatigue, nausea, headache, and cold hands or feet.
• Serious (Less Common) Side Effects:
  • Severe bradycardia (slow heart rate), shortness of breath, swelling in the legs, or fainting.

Important Information:

• Dosage Instruction: Take as directed by your healthcare provider. Do not skip or stop without consulting your doctor.
• Usage Instruction: Swallow the tablet whole with water, with or without food.
• General Information:
  • Avoid this medication if allergic to bisoprolol or other beta-blockers.
  • Inform your doctor if you have asthma, severe heart conditions, or kidney/liver problems.
  • Consult your doctor if you are pregnant, breastfeeding, or planning to conceive.

Drug Interactions:

• Interactions with Other Medications:
  • May interact with calcium channel blockers (e.g., verapamil), antiarrhythmics, or diabetes medications.
• Interactions with Food:
  • Alcohol may enhance dizziness or drowsiness.

Regulatory Approval & Manufacturer:
Approved by [regulatory authority], manufactured by [manufacturer].

Antidotes (If Overdose or Misuse):
Overdose can cause severe bradycardia, hypotension, or heart block. Seek immediate medical attention. Supportive treatments include atropine or glucagon administration.

For Pharmacists:

Medicine Name: Actim
Brand: Actim
Active Ingredient(s): Bisoprolol Fumarate 10 mg

Indications:

• Hypertension management.
• Treatment of chronic stable angina.
• Adjunctive therapy in heart failure.

Pharmacodynamics:

• Mechanism of Action:
  Bisoprolol selectively blocks beta-1 adrenergic receptors in the heart, reducing heart rate, myocardial contractility, and cardiac output. This lowers blood pressure and decreases oxygen demand.
• Pharmacological Effects:
  • Lowers blood pressure and heart rate.
  • Relieves symptoms of angina.
• Receptor Binding:
  Bisoprolol binds selectively to beta-1 adrenergic receptors in cardiac tissue, minimizing effects on beta-2 receptors in the lungs and peripheral blood vessels.

Pharmacokinetics:

• Absorption: Well-absorbed orally, bioavailability ~90%.
• Distribution: Limited crossing of the blood-brain barrier; plasma protein binding ~30%.
• Metabolism: Metabolized in the liver (minor contribution via CYP enzymes).
• Elimination: Excreted equally through urine and feces.
• Half-Life: 10-12 hours.
• Effect of Food: Minimal impact on absorption or efficacy.

Dosage and Administration:

• Adults: 10 mg once daily.
• Pediatric: Not recommended.
• Special Populations:
  • Renal Impairment: Dose adjustment may be necessary; monitor renal function.
  • Hepatic Impairment: Administer with caution and adjust dose as needed.

Contraindications:

• Known hypersensitivity to bisoprolol or beta-blockers.
• Severe bradycardia, cardiogenic shock, or second/third-degree heart block.
• Untreated pheochromocytoma or severe asthma.

Warnings and Precautions:

• Use with caution in diabetes patients, as bisoprolol may mask hypoglycemia symptoms.
• Abrupt discontinuation may cause rebound hypertension or angina.

Drug-Drug Interactions:

• May interact with:
  • Calcium channel blockers (e.g., verapamil, diltiazem).
  • Antiarrhythmics, NSAIDs, or hypoglycemic agents.
• Monitoring Required: Blood pressure, heart rate, and renal function during therapy.

Drug-Food Interactions:

• Alcohol may potentiate side effects such as dizziness or drowsiness.

Adverse Reactions:

• Common: Fatigue, dizziness, nausea, headache, and cold extremities.
• Serious: Severe bradycardia, heart failure exacerbation, bronchospasm, or anaphylaxis.

Therapeutic Effects:

• Reduces myocardial oxygen demand, controlling hypertension and angina symptoms effectively.

Storage:
Store at 15-30°C in a dry, light-protected environment.

Packaging:
Blister pack containing 14 tablets.

Clinical Considerations:

• Pregnancy Category: C (Use only if benefits outweigh risks).
• Lactation: Excreted in breast milk; use cautiously.
• Pediatric: Not suitable for children.
• Geriatric: Initiate with a lower dose, monitor closely for adverse effects.

Conclusion:

Actim Tab 10 mg is an effective beta-blocker for managing hypertension, angina, and heart failure. Its higher dose is suitable for patients requiring greater blood pressure or heart rate control. Adherence to prescribed usage and monitoring of side effects are essential for patient safety and therapeutic success. Always consult a healthcare professional for any concerns.