Actigem Tab 320 mg 7’s-Potential Overview:

Brand Name: Actigem
Generic Name: Gemifloxacin
Active Ingredient(s): Gemifloxacin Mesylate 320 mg

For the General Public:

Uses:
Actigem is commonly used to treat:

• Bacterial infections such as bronchitis and pneumonia.
• Certain skin and soft tissue infections.

It works by inhibiting bacterial DNA synthesis, preventing the growth and replication of bacteria.

Dosage:

• Usual Dose: One tablet (320 mg) once daily for 5-7 days, depending on the type and severity of the infection.
• Always follow the prescribed course and instructions from your healthcare provider.

Possible Side Effects:

• Common Side Effects:
  • Nausea, diarrhea, headache, dizziness, and stomach discomfort.
• Serious (Less Common) Side Effects:
  • Tendon rupture, severe allergic reactions, liver dysfunction, or irregular heartbeats.

Important Information:

• Dosage Instruction: Do not exceed the prescribed dose. Complete the full course even if you feel better.
• Usage Instruction: Take with water, with or without food. Avoid taking with antacids, multivitamins, or dairy products within 2 hours.
• General Information:
  • Avoid this medicine if allergic to gemifloxacin or other fluoroquinolones.
  • Consult your doctor if you are pregnant, breastfeeding, or planning to conceive.
  • Keep out of reach of children.

Drug Interactions:

• Interactions with Other Medications:
  • May interact with anticoagulants (e.g., warfarin), antacids, or antiarrhythmic drugs.
• Interactions with Food:
  • Avoid taking with calcium-rich foods or supplements, as they may reduce the drug’s absorption.

Regulatory Approval & Manufacturer:
Approved by [regulatory authority], manufactured by [manufacturer].

Antidotes (If Overdose or Misuse):
Overdose symptoms may include confusion, dizziness, or seizures. Seek immediate medical attention.

For Pharmacists:

Medicine Name: Actigem
Brand: Actigem
Active Ingredient(s): Gemifloxacin Mesylate 320 mg

Indications:

• Treatment of bacterial infections such as:
  • Acute bacterial exacerbation of chronic bronchitis (ABECB).
  • Community-acquired pneumonia (CAP).
  • Uncomplicated skin and soft tissue infections.

Pharmacodynamics:

• Mechanism of Action:
  Gemifloxacin inhibits bacterial DNA gyrase and topoisomerase IV, enzymes essential for DNA replication, transcription, and repair.
• Pharmacological Effects:
  • Effective against Gram-positive and Gram-negative bacteria.
• Receptor Binding:
  Gemifloxacin targets bacterial enzymes selectively, sparing human topoisomerases.

Pharmacokinetics:

• Absorption: Rapidly absorbed; bioavailability ~70%.
• Distribution: Wide tissue distribution; plasma protein binding ~60%.
• Metabolism: Minimally metabolized in the liver.
• Elimination: Excreted via urine and feces.
• Half-Life: Approximately 7 hours.
• Effect of Food: Food delays absorption but does not affect overall bioavailability significantly.

Dosage and Administration:

• Adults: One tablet (320 mg) once daily for 5-7 days.
• Pediatric: Not recommended.
• Special Populations:
  • Renal Impairment: Adjust dose if creatinine clearance <40 mL/min.
  • Hepatic Impairment: Use with caution; no specific dosage adjustment required.

Contraindications:

• Hypersensitivity to gemifloxacin or other fluoroquinolones.
• History of tendon disorders associated with fluoroquinolone use.

Warnings and Precautions:

• Use cautiously in patients with:
  • Tendonitis or history of tendon rupture.
  • QT prolongation or other cardiac conditions.
  • CNS disorders (e.g., seizures).
• Avoid excessive sun exposure; may cause photosensitivity.

Drug-Drug Interactions:

• May interact with:
  • Antacids or supplements containing magnesium, aluminum, calcium, or iron (reduce absorption).
  • Antiarrhythmic drugs, as they may prolong QT interval.
  • Warfarin (may increase anticoagulant effects).

Drug-Food Interactions:

• Avoid dairy products or calcium-fortified juices close to dosing, as they may decrease absorption.

Adverse Reactions:

• Common: Diarrhea, nausea, headache, dizziness.
• Serious: Tendon rupture, QT prolongation, hypersensitivity reactions, and liver dysfunction.

Therapeutic Effects:

• Rapid and effective bacterial eradication for indicated infections.

Storage:
Store at 15-25°C in a dry, light-protected environment.

Packaging:
Blister pack containing 7 tablets.

Clinical Considerations:

• Pregnancy Category: C (Use only if clearly needed).
• Lactation: Excretion in breast milk unknown; use cautiously.
• Pediatric: Safety and efficacy not established.
• Geriatric: Increased risk of tendon disorders; monitor closely.

Conclusion:

Actigem Tab 320 mg is an effective fluoroquinolone antibiotic for treating respiratory and skin infections. Patients should adhere to the prescribed regimen and be cautious about potential side effects, particularly tendon issues and QT prolongation. Proper storage and avoidance of interactions with antacids or calcium-rich products are essential for optimal efficacy. Always consult a healthcare provider for any concerns.