Actifed P Tab 400’s-Potential Overview:

Brand Name: Actifed P
Generic Name: Triprolidine Hydrochloride + Pseudoephedrine Hydrochloride
Active Ingredient(s):

• Triprolidine Hydrochloride
• Pseudoephedrine Hydrochloride

For the General Public:

Uses:
Actifed P is commonly used for the symptomatic relief of:

• Nasal congestion associated with colds, allergies, or sinusitis.
• Hay fever and other upper respiratory allergies.

How It Works:

• Triprolidine Hydrochloride: An antihistamine that blocks the effects of histamine, relieving symptoms like sneezing and runny nose.
• Pseudoephedrine Hydrochloride: A decongestant that reduces nasal swelling and congestion by shrinking blood vessels in the nasal passages.

Dosage:

• Adults and children over 12 years: 1 tablet every 4-6 hours, not exceeding 4 tablets in 24 hours.
• Always follow the instructions on the packaging or as prescribed by your doctor.

Possible Side Effects:

• Common Side Effects:
  • Drowsiness, dizziness, dry mouth, headache, nausea.
• Serious (Less Common) Side Effects:
  • Increased heart rate, high blood pressure, hallucinations, or severe allergic reactions.

Important Information:

• Dosage Instruction: Do not exceed the recommended dose.
• Usage Instruction: Take with or without food.
• General Information:
  • Avoid alcohol and other sedatives while taking this medication.
  • Do not use if allergic to any ingredients.
  • Consult your doctor if pregnant, breastfeeding, or planning to conceive.
  • Keep out of reach of children.

Drug Interactions:

• Interactions with Other Medications:
  • May interact with monoamine oxidase inhibitors (MAOIs), beta-blockers, or sedatives.
• Interactions with Food:
  • Avoid alcohol, which can enhance drowsiness.

Regulatory Approval & Manufacturer:
Approved by [regulatory authority], manufactured by [manufacturer].

Antidotes (If Overdose or Misuse):
Overdose symptoms may include restlessness, rapid heartbeat, or severe drowsiness. Seek immediate medical attention.

For Pharmacists:

Medicine Name: Actifed P
Brand: Actifed P
Active Ingredient(s):

• Triprolidine Hydrochloride
• Pseudoephedrine Hydrochloride

Indications:

• Relief of nasal congestion and associated allergic symptoms.

Pharmacodynamics:

• Mechanism of Action:
  • Triprolidine Hydrochloride: A competitive H1 receptor antagonist, reducing the effects of histamine on H1 receptors.
  • Pseudoephedrine Hydrochloride: Acts as a sympathomimetic agent, stimulating alpha-adrenergic receptors to reduce nasal swelling and improve airflow.
• Pharmacological Effects:
  • Relieves allergy symptoms such as sneezing, itching, and nasal congestion.
• Receptor Binding:
  • Triprolidine binds to H1 histamine receptors.
  • Pseudoephedrine activates alpha-adrenergic receptors in the nasal mucosa.

Pharmacokinetics:

• Absorption: Well absorbed orally, with onset of action within 15-30 minutes.
• Distribution: Widely distributed in body tissues; pseudoephedrine crosses the blood-brain barrier.
• Metabolism:
  • Triprolidine is metabolized in the liver.
  • Pseudoephedrine undergoes partial hepatic metabolism.
• Elimination: Excreted primarily in urine.
• Half-Life:
  • Triprolidine: ~3-5 hours.
  • Pseudoephedrine: ~5-8 hours.

Dosage and Administration:

• Adults and Children >12 years: 1 tablet every 4-6 hours, maximum of 4 tablets per day.
• Pediatric: Not recommended for children under 12 years.

Contraindications:

• Hypersensitivity to any component.
• Severe hypertension, coronary artery disease, or use of MAOIs within 14 days.

Warnings and Precautions:

• Use cautiously in patients with:
  • Cardiovascular disease, diabetes, hyperthyroidism, or glaucoma.
  • Prostatic hypertrophy or urinary retention.

Drug-Drug Interactions:

• Avoid concurrent use with:
  • MAOIs, beta-blockers, or CNS depressants.

Drug-Food Interactions:

• Avoid alcohol to reduce risk of enhanced drowsiness.

Adverse Reactions:

• Common: Drowsiness, headache, dry mouth, and mild gastrointestinal discomfort.
• Serious: Palpitations, hypertension, or severe hypersensitivity reactions.

Therapeutic Effects:

• Quick relief of nasal congestion and allergic symptoms.

Storage:
Store at 15-25°C, in a cool and dry place away from light.

Packaging:
Pack of 400 tablets.

Clinical Considerations:

• Pregnancy Category: C (Use only if clearly needed).
• Lactation: Use with caution; may pass into breast milk.
• Pediatric: Not recommended for children under 12 years.
• Geriatric: Increased sensitivity to side effects; monitor closely.

Conclusion:

Actifed P Tab 400’s is a reliable combination therapy for managing nasal congestion and allergic symptoms. Patients should adhere to dosage guidelines and avoid activities requiring alertness if drowsiness occurs. Pharmacists should counsel patients on potential interactions and advise caution for individuals with pre-existing conditions or those taking other medications.