Acenac Tab 100 mg 3×10’s-Potential Overview:

Brand Name: Acenac
Generic Name: Aceclofenac
Active Ingredient(s): Aceclofenac 100 mg

For the General Public:

Uses:
Acenac is commonly used to:

• Relieve pain and inflammation in conditions like osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis.
• Provide symptomatic relief for acute musculoskeletal disorders.

How It Works:
Aceclofenac is a nonsteroidal anti-inflammatory drug (NSAID) that reduces inflammation and pain by inhibiting the production of prostaglandins, chemicals in the body responsible for inflammation, pain, and fever.

Dosage:

• Adults: One 100 mg tablet twice daily, taken with or after food.
• Children: Not recommended for children unless specifically prescribed by a doctor.

Possible Side Effects:

• Common Side Effects: Nausea, vomiting, abdominal pain, diarrhea, dizziness, and skin rash.
• Serious Side Effects: Gastrointestinal bleeding, severe allergic reactions, liver dysfunction (e.g., jaundice), kidney impairment, and cardiovascular issues.

Important Information:

• Dosage Instruction: Follow the prescribed dosage strictly; do not exceed the recommended dose.
• Usage Instruction: Take with food or milk to reduce the risk of stomach upset.
• General Information:
  • Avoid if allergic to NSAIDs (e.g., ibuprofen, aspirin).
  • Consult your doctor if pregnant, breastfeeding, or taking other medications.
  • Store in a cool, dry place, away from direct sunlight.

Drug Interactions:

• Interactions with Other Medications:
  • Increased risk of bleeding with anticoagulants (e.g., warfarin).
  • Reduced efficacy of antihypertensive drugs (e.g., ACE inhibitors, beta-blockers).
• Interactions with Food:
  • Alcohol consumption increases the risk of gastrointestinal bleeding.

Regulatory Approval & Manufacturer:
Approved by [regulatory authority], manufactured by [manufacturer].

Antidotes (If Overdose or Misuse):
Symptoms of overdose include nausea, vomiting, dizziness, and confusion. Seek immediate medical attention for symptomatic management and supportive care.

For Pharmacists:

Medicine Name: Acenac
Brand: Acenac
Active Ingredient(s): Aceclofenac 100 mg

Indications:

• Management of pain and inflammation in osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis.
• Treatment of acute musculoskeletal pain and post-operative pain.

Pharmacodynamics:

• Mechanism of Action:
  Aceclofenac inhibits cyclooxygenase (COX-2 > COX-1), reducing prostaglandin synthesis and thereby alleviating pain and inflammation.
• Pharmacological Effects:
  • Anti-inflammatory.
  • Analgesic (pain-relieving).
  • Antipyretic (fever-reducing).
• Receptor Binding:
  Aceclofenac indirectly modulates prostaglandin activity by inhibiting their synthesis and does not bind directly to prostaglandin receptors.

Pharmacokinetics:

• Absorption: Rapidly absorbed; peak plasma concentration occurs within 1.25-3 hours.
• Distribution: High plasma protein binding (~99%).
• Metabolism: Extensively metabolized in the liver to active metabolites, primarily 4′-hydroxyaceclofenac.
• Elimination: Excreted in urine as metabolites.
• Half-Life: 4-4.3 hours.
• Effect of Food: Food may slightly delay absorption but does not affect overall bioavailability.

Dosage and Administration:

• Adults: 100 mg twice daily with or after food.
• Pediatric: Not recommended unless prescribed.
• Special Populations:
  • Use cautiously in elderly patients and those with hepatic or renal impairment.

Contraindications:

• Hypersensitivity to aceclofenac or other NSAIDs.
• Active or recurrent peptic ulcers, gastrointestinal bleeding, or severe liver/kidney impairment.
• Pregnancy (especially third trimester).

Warnings and Precautions:

• Increased risk of cardiovascular events (e.g., heart attack, stroke) with prolonged use.
• Monitor for signs of gastrointestinal bleeding or ulceration, especially in at-risk populations.
• Use cautiously in patients with hypertension, heart failure, or renal impairment.

Drug-Drug Interactions:

• Increased bleeding risk with anticoagulants (e.g., warfarin).
• Reduced efficacy of antihypertensives (e.g., ACE inhibitors, diuretics).
• Potential toxicity with methotrexate and lithium.

Drug-Food Interactions:

• Alcohol consumption can increase the risk of gastrointestinal irritation or bleeding.

Adverse Reactions:

• Common: Nausea, vomiting, abdominal pain, headache, dizziness.
• Serious: Gastrointestinal bleeding, severe allergic reactions, liver dysfunction, kidney impairment.

Therapeutic Effects:

• Provides effective relief from pain and inflammation associated with musculoskeletal disorders.

Storage:
Store at 15-30°C in a dry place, away from moisture and direct sunlight.

Packaging:
Available in packs of 3×10 tablets (100 mg each).

Clinical Considerations:

• Pregnancy Category: C (avoid in the third trimester).
• Lactation: Use cautiously as it may pass into breast milk.
• Pediatric: Not recommended unless prescribed.
• Geriatric: Increased risk of gastrointestinal and renal side effects.

Conclusion:

Acenac Tab 100 mg 3×10’s is an effective NSAID for managing pain and inflammation in arthritis and other musculoskeletal conditions. Patients should follow the prescribed dosage and take the medication with food to minimize stomach upset. Pharmacists should educate patients on potential drug interactions and advise caution in special populations, including the elderly and those with pre-existing medical conditions. Proper usage ensures optimal therapeutic outcomes with minimized risks.