Abiclot 75mg Tab 10s-Potential Overview

For the General Public:

1. Medicine Name:Abiclot 75mg Tablets
2. Brand:Abiclot
3. Active Ingredient(s):Clopidogrel bisulfate
4. Uses:
   Abiclot is commonly used to prevent blood clots that can lead to heart attacks or strokes. It works by inhibiting platelets (a type of blood cell) from clumping together, reducing the formation of harmful clots.
5. Dosage:
   Take one tablet daily, with or without food, as directed by your doctor. Follow the instructions on the packaging or as prescribed.
6. Possible Side Effects:
   Common side effects include:
   • Headache
   • Dizziness
   • Nausea
   • Diarrhea
     If you experience unusual symptoms like signs of bleeding (e.g., nosebleeds, blood in urine), seek medical advice immediately.
7. Important Information:
   • Do not take this medicine if allergic to clopidogrel or any other ingredient.
   • Inform your doctor if you have liver disease, bleeding disorders, or if you are pregnant or breastfeeding.
   • Avoid activities with a high risk of injury as this medication increases bleeding risk.
   • Store out of reach of children.

For Pharmacists:

1. Medicine Name:Abiclot 75mg Tablets
2. Brand:Abiclot
3. Active Ingredient(s):Clopidogrel bisulfate
4. Indications:
   Abiclot 75mg is indicated for the prevention of atherothrombotic events such as:
   • Recent myocardial infarction (MI)
   • Stroke
   • Peripheral arterial disease (PAD)
     It is also indicated for patients with acute coronary syndrome (ACS) and in conjunction with aspirin for prevention of further cardiovascular events.
5. Pharmacodynamics:
   • Mechanism of Action:
     Clopidogrel is a prodrug that is metabolized by liver enzymes (CYP2C19) to form an active metabolite. This active metabolite irreversibly inhibits the P2Y12 ADP receptor on platelets, preventing ADP-mediated platelet aggregation. This leads to prolonged inhibition of platelet activation and aggregation, thereby reducing the risk of thrombotic events.
   • Pharmacological Effects:
     Clopidogrel reduces the formation of blood clots by inhibiting platelet aggregation. This is crucial in preventing cardiovascular events such as heart attacks, strokes, and peripheral arterial events.
   • Receptor Binding:
     The active metabolite of clopidogrel binds irreversibly to the P2Y12 ADP receptors on platelets. This inhibition of platelet aggregation persists for the lifespan of the platelet (7–10 days).
6. Pharmacokinetics:
   • Absorption:
     Clopidogrel is well absorbed after oral administration, with peak plasma concentrations typically occurring 30 to 60 minutes after dosing.
   • Distribution:
     The drug is highly protein-bound (approximately 98%) and has a volume of distribution (Vd) of approximately 56 liters.
   • Metabolism:
     Clopidogrel is extensively metabolized in the liver by CYP enzymes, particularly CYP2C19, to produce an active thiol metabolite. The half-life of the active metabolite is approximately 30 minutes, while the half-life of the parent drug is about 6 hours.
   • Elimination:
     The active metabolite is mainly excreted through urine (approximately 50% of the dose), with the remainder excreted in feces.
   • Half-Life:
     The elimination half-life of clopidogrel is approximately 6 hours for the parent compound. However, the pharmacodynamic effects last much longer due to irreversible platelet inhibition.
   • Bioavailability:
     The bioavailability of clopidogrel after oral administration is approximately 50%.
   • Time to Peak Concentration:
     The time to peak concentration is about 30 to 60 minutes post-administration.
   • Effect of Food:
     Food does not significantly affect the absorption of clopidogrel. The drug can be taken with or without food.
7. Dosage and Administration:
   • Adults:
     The recommended dosage for adults is 75mg daily, with or without food. The dose is usually continued for long-term management of cardiovascular risks.
   • Pediatric:
     There is limited information available for pediatric use; the medicine is not typically recommended for children under 18.
   • Special Populations:
     In elderly patients or those with renal or hepatic impairment, dosage adjustments may be required. Consultation with a healthcare provider is necessary.
8. Contraindications:
   • Known hypersensitivity to clopidogrel or any other ingredient in the formulation.
   • Contraindicated in patients with active bleeding disorders such as peptic ulcer disease, intracranial hemorrhage, or gastrointestinal bleeding.
   • Use is contraindicated in patients with severe hepatic impairment.
9. Warnings and Precautions:
   • Bleeding Risk:
     Clopidogrel increases the risk of bleeding. Caution should be exercised when prescribing it to patients with bleeding disorders, recent surgery, or trauma.
   • Liver Disease:
     Use with caution in patients with liver impairment as the drug is metabolized in the liver.
   • Discontinuation Prior to Surgery:
     Patients should stop taking clopidogrel at least 5 days before elective surgery to reduce the risk of bleeding.
   • Thrombocytopenia:
     Use with caution in patients with low platelet counts or other conditions affecting platelet function.
10. Drug Interactions:
    • Aspirin or Other Antiplatelet Drugs:
      When used in combination with other antiplatelet agents, the risk of bleeding increases.
    • Anticoagulants:
      Concurrent use with warfarin or other anticoagulants should be avoided or closely monitored due to the potential for excessive bleeding.
    • CYP2C19 Inhibitors:
      Drugs that inhibit CYP2C19 (e.g., omeprazole) may reduce the effectiveness of clopidogrel.
11. Adverse Reactions:
    • Common Adverse Effects:
      • Headache
      • Dizziness
      • Nausea
      • Diarrhea
      • Bleeding complications such as nosebleeds, easy bruising, or prolonged bleeding
    • Serious Adverse Effects:
      • Severe bleeding (e.g., gastrointestinal or intracranial bleeding)
      • Thrombotic thrombocytopenic purpura (TTP), a rare but serious condition
      • Allergic reactions (e.g., rash, difficulty breathing, swelling of the face or throat)

Final Conclusion:

1. Effectiveness:
   Abiclot 75mg is a highly effective antiplatelet medication used to prevent thrombotic cardiovascular events (e.g., heart attacks and strokes) in at-risk patients.
2. Mechanism of Action:
   The drug works by irreversibly inhibiting the P2Y12 ADP receptors on platelets, thus preventing platelet aggregation and reducing the risk of clot formation.
3. Pharmacological Benefits:
   Abiclot provides essential protection against cardiovascular events in patients with a history of acute coronary syndrome, stroke, or peripheral arterial disease.
4. Patient Education:
   Patients should follow prescribed dosage instructions, be aware of potential side effects, and consult their healthcare provider if any unusual symptoms occur. Adherence to treatment is crucial for optimal results.
5. Precautions:
   Special care is required for patients with bleeding risks, hepatic impairment, or those on concurrent anticoagulant therapy. Pharmacists should ensure proper education and counseling on the medication’s usage.
6. Storage & Handling:
   Proper storage is important to maintain efficacy. The medicine should be stored at room temperature in a tightly closed container, away from moisture and light.