A2a Tab 50 mg 10’s-Potential Overview:

Brand Name: A2a
Generic Name: Amlodipine
Active Ingredient(s): Amlodipine besylate

For the General Public:

Uses:
A2a 50 mg is commonly used to:

• Treat high blood pressure (hypertension).
• Manage angina (chest pain).

How It Works:
Amlodipine is a calcium channel blocker. It works by relaxing and widening blood vessels, which helps to lower blood pressure and reduce the heart’s workload.

Dosage:

• Take 50 mg once daily or as prescribed by your doctor.
• Can be taken with or without food.

Possible Side Effects:

• Common Side Effects: Dizziness, headache, swelling in ankles or feet, flushing.
• Serious Side Effects: Severe hypotension, palpitations, chest pain, severe allergic reactions.

Important Information:

• Dosage Instruction: Follow the prescribed dose exactly; do not double up or skip doses without consulting your doctor.
• Usage Instruction: Swallow the tablet whole with water. Avoid crushing or chewing.
• General Information:
  • Avoid grapefruit or grapefruit juice as it may interact with amlodipine and increase side effects.
  • Notify your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding.
  • Keep the medication out of reach of children.
  • If you miss a dose, take it as soon as you remember unless it is close to the next scheduled dose.

Drug Interactions:

• With Other Medications: May interact with medications like beta-blockers, ACE inhibitors, and other antihypertensive drugs.
• With Food: Grapefruit and grapefruit juice may increase drug levels.

Regulatory Approval & Manufacturer:
Approved by [authority], manufactured by [manufacturer].

Antidotes (If Overdose or Misuse):
In case of overdose, symptoms may include severe hypotension, dizziness, and bradycardia. Supportive measures such as IV fluids may be required.

For Pharmacists:

Medicine Name: A2a
Brand: A2a
Active Ingredient(s): Amlodipine besylate

Indications:

• Hypertension.
• Angina.

Pharmacodynamics:

• Mechanism of Action: Amlodipine blocks calcium channels in the smooth muscle of blood vessels, leading to relaxation and vasodilation, which lowers blood pressure and reduces the frequency and severity of angina.
• Pharmacological Effects: Reduces blood pressure, alleviates anginal pain by reducing myocardial oxygen demand.
• Receptor Binding: Selectively binds to L-type calcium channels with high specificity.

Pharmacokinetics:

• Absorption: Rapidly absorbed with a peak plasma concentration within 6–12 hours.
• Distribution: Highly protein-bound in plasma, with a large volume of distribution (Vd).
• Metabolism: Primarily metabolized in the liver via CYP3A4.
• Elimination: Excreted in urine and feces, with a half-life of approximately 30–50 hours.
• Bioavailability: About 64% after oral administration.
• Effect of Food: Grapefruit and grapefruit juice may increase drug levels, avoid concurrent use.

Dosage and Administration:

• Adults: Start with 5 mg daily, can be increased to a maximum of 10 mg daily based on clinical response.
• Pediatric Use: Not recommended.
• Special Populations: Use with caution in hepatic and renal impairment, dose adjustments may be needed.

Contraindications:

• Hypersensitivity to amlodipine or any of its excipients.
• Severe aortic stenosis.

Warnings and Precautions:

• Monitor for signs of hypotension and peripheral edema.
• Use with caution in patients with hepatic or renal impairment.
• Grapefruit or grapefruit juice may interact with amlodipine and increase plasma concentrations.

Drug-Drug Interactions:

• With Beta-Blockers: Increased risk of hypotension.
• With ACE Inhibitors: May enhance antihypertensive effects.
• With Grapefruit Juice: Increases drug levels and potential side effects.

Drug-Food Interactions:

• With Grapefruit: Increases absorption, leading to higher drug levels and risk of side effects.

Adverse Reactions:

• Common: Dizziness, headache, fatigue, peripheral edema.
• Serious: Severe hypotension, palpitations, bradycardia, and allergic reactions.

Therapeutic Effects:

• Effectively reduces blood pressure and alleviates anginal symptoms.

Storage:
Store at 15–30°C in a dry place away from direct sunlight.

Packaging:
Available as 50 mg tablets in blister packs containing 10 tablets.

Clinical Considerations:

• Pregnancy Category: C (Risk cannot be ruled out).
• Lactation: Use with caution, as it may be excreted in breast milk.
• Geriatric Use: Adjust dose carefully due to increased sensitivity.

Conclusion:

A2a Tab 50 mg is a calcium channel blocker used for managing hypertension and angina. Proper adherence to dosing instructions is crucial to achieving optimal therapeutic outcomes while minimizing potential adverse effects.