Amper Tab 10/4mg 10s-Potential Overview

Brand Name:

Amper Tab 10/4mg

Active Ingredients:

1. Amlodipine – 10 mg
   (Calcium Channel Blocker)
2. Perindopril – 4 mg
   (ACE Inhibitor)

Uses:

• Management of high blood pressure (hypertension)
• Prevention of cardiovascular events such as heart attack or stroke in patients with specific conditions.

Dosage:

• Usual Dose: 1 tablet daily.
• Adjusted by a healthcare provider based on individual response and clinical factors.
• Can be taken with or without food, preferably at the same time each day.

Possible Side Effects:

• Common: Dizziness, headache, fatigue, dry cough, nausea.
• Rare but serious: Angioedema, chest pain, palpitations, or difficulty breathing.
• Seek medical attention for severe or persistent side effects.

For Pharmacists 

Brand Name:

Amper Tab 10/4mg

Active Ingredients:

1. Amlodipine – 10 mg
   (Calcium Channel Blocker)
2. Perindopril – 4 mg
   (ACE Inhibitor)

Indications:

• Treatment of hypertension.
• Prevention of coronary artery disease complications in at-risk individuals.

Pharmacodynamics: Mechanism of Action:

1. Amlodipine: Blocks calcium channels in vascular smooth muscle, reducing vascular resistance and leading to vasodilation.
2. Perindopril: Inhibits the enzyme that converts angiotensin I to angiotensin II, decreasing vasoconstriction and promoting diuresis.

Pharmacological Effects:

• Reduces blood pressure by decreasing peripheral resistance.
• Enhances coronary artery perfusion.
• Exhibits long-term benefits in cardiovascular protection.

Receptor Binding:

• Amlodipine: Binds to L-type calcium channels.
• Perindopril: Binds to and inhibits the angiotensin-converting enzyme (ACE).

Dosage and Administration:

• Start with 1 tablet daily.
• Monitor blood pressure, renal function, and potassium levels regularly.
• Adjust dosage in patients with renal impairment or the elderly.

Contraindications:

• Hypersensitivity to amlodipine, perindopril, or ACE inhibitors.
• Pregnancy and lactation.
• Severe hypotension, shock, or obstructive heart conditions.

Warnings & Precautions:

• Monitor for angioedema and discontinue if it occurs.
• Caution in patients with renal or hepatic impairment.
• Avoid concomitant use with potassium-sparing diuretics or supplements.

Drug Interactions:

• Increased risk of hyperkalemia with potassium supplements.
• Reduced antihypertensive effect with NSAIDs.
• Enhanced effects when combined with other antihypertensive drugs.
• Avoid grapefruit juice as it can increase amlodipine plasma concentration.

Adverse Reactions:

• Common: Edema, dizziness, flushing, fatigue.
• Serious: Hypotension, renal impairment, severe allergic reactions.

Storage Instructions:

• Store in a cool, dry place at room temperature.
• Protect from light and moisture.

Packaging Information:

• Form: Tablets
• Pack Size: 10 tablets per pack.

Conclusion

Mechanism of Action

Amper Tab combines two active components:

1. Amlodipine: A calcium channel blocker that relaxes blood vessels by inhibiting calcium influx, reducing vascular resistance.
2. Perindopril: An ACE inhibitor that prevents the conversion of angiotensin I to angiotensin II, decreasing vasoconstriction and promoting fluid balance. This dual mechanism offers comprehensive blood pressure control and cardiovascular protection.

Pharmacological Effects

• Blood Pressure Reduction: By relaxing blood vessels and reducing fluid retention, the combination lowers both systolic and diastolic blood pressure.
• Organ Protection: Provides renoprotective and cardioprotective benefits, especially in patients at high cardiovascular risk.
• Synergistic Action: The two agents work together to prevent the side effects commonly seen with monotherapy, such as reflex tachycardia.

Receptor Binding

• Amlodipine: Targets L-type calcium channels in vascular smooth muscle, leading to vasodilation.
• Perindopril: Inhibits ACE and increases bradykinin availability, enhancing vasodilation and reducing arterial stiffness.

Summary of Indications and Use

• Indications: Primary hypertension, prevention of cardiovascular events (e.g., heart attacks or strokes).
• Use: A once-daily tablet for adult patients who need effective long-term blood pressure management. Particularly suited for those with coexisting cardiovascular risks.

Key Patient Instructions

• Adherence: Take the medication consistently at the same time daily, with or without food.
• Side Effects: Monitor for symptoms like dizziness, swelling, or dry cough, and report severe reactions to a healthcare provider.
• Avoid: Potassium-rich supplements or salt substitutes and grapefruit juice, as these may interact with the drug.

Final Thoughts

Amper Tab 10/4mg offers a potent, well-tolerated option for managing hypertension and reducing cardiovascular risk. Its dual mechanism ensures efficacy, while its once-daily dosing promotes patient adherence. When prescribed and monitored correctly, it can significantly improve quality of life and long-term health outcomes. Always consult a healthcare professional before starting or adjusting the treatment.