Adalat LA Tab 60 mg 2×10’s-Potential Overview:

Brand Name: Adalat
Generic Name: Nifedipine
Active Ingredient(s): Nifedipine 60 mg

For the General Public:

Uses:
Adalat LA is used to:

• Manage hypertension (high blood pressure).
• Treat chronic stable angina (chest pain).
• Manage certain types of vascular disorders.

Dosage:

• Hypertension and Angina: 60 mg once daily.
• Dosage may be adjusted based on patient response.

Possible Side Effects:

• Common Side Effects: Dizziness, headache, flushing, peripheral edema.
• Serious (Less Common) Side Effects:
  • Severe hypotension (low blood pressure).
  • Tachycardia (fast heart rate).
  • Heart-related issues like arrhythmias.

Important Information:

• Dosage Instruction: Take exactly as prescribed, preferably at the same time each day.
• Usage Instruction: Can be taken with or without food.
• General Information:
  • Not recommended for patients with severe aortic stenosis or unstable angina.
  • Caution in patients with impaired liver function.

Drug Interactions:

• Interactions with Other Medications:
  • Increased risk of hypotension when combined with other antihypertensive medications.
  • Potential interaction with medications affecting heart rate or conduction.
• Interactions with Food:
  • Grapefruit juice may increase nifedipine levels, leading to enhanced side effects.

Regulatory Approval & Manufacturer:
Approved by [regulatory authority], manufactured by [manufacturer].

Antidotes (If Overdose or Misuse by Patients):

• In cases of overdose, supportive care including fluid management and vasopressors may be required. Seek immediate medical attention.

For Pharmacists:

Medicine Name: Adalat LA
Brand: Adalat
Active Ingredient(s): Nifedipine 60 mg

Indications:

• Treatment of hypertension.
• Chronic stable angina.
• Certain vascular disorders.

Pharmacodynamics:

• Mechanism of Action:
  Nifedipine is a calcium channel blocker that inhibits the influx of calcium ions into smooth muscle and myocardial cells, reducing vascular resistance and myocardial oxygen demand.
• Pharmacological Effects:
  • Relaxes arterial smooth muscle, leading to vasodilation and reduced blood pressure.
  • Reduces frequency and intensity of angina attacks.
• Receptor Binding:
  Binds selectively to L-type calcium channels in vascular smooth muscle and myocardial tissue.

Pharmacokinetics:

• Absorption: Rapidly absorbed, with peak plasma concentration within 30-60 minutes.
• Distribution: Extensive tissue distribution, with a high volume of distribution.
• Metabolism: Hepatic metabolism via the CYP3A4 pathway.
• Elimination: Primarily excreted via urine.
• Half-Life: Approximately 6-8 hours.
• Effect of Food: Food slows down the absorption of nifedipine, reducing peak plasma concentration.

Dosage and Administration:

• Adults:
  • 60 mg once daily, adjusted based on patient’s blood pressure and response.
• Special Populations:
  • Monitor closely in patients with hepatic impairment or older adults.

Contraindications:

• Severe hypotension, shock.
• Known hypersensitivity to nifedipine or its excipients.
• Unstable angina or acute myocardial infarction.

Warnings and Precautions:

• Use with caution in:
  • Patients with liver impairment or heart failure.
  • Patients at risk of hypotension.

Drug-Drug Interactions:

• Increased risk of hypotension when combined with other antihypertensive drugs.
• Grapefruit juice can increase nifedipine levels, potentially causing toxicity.

Drug-Food Interactions:

• Grapefruit juice can enhance nifedipine absorption and effects.

Adverse Reactions:

• Common: Dizziness, headache, flushing, peripheral edema.
• Serious: Severe hypotension, arrhythmias, peripheral swelling.

Therapeutic Effects:

• Effective in lowering blood pressure and relieving angina by relaxing vascular smooth muscle and reducing myocardial oxygen demand.

Storage:
Store at 15-30°C, protected from light and moisture.

Packaging:
Available in blister packs of 2×10 tablets.

Clinical Considerations:

• Pregnancy Category: C (use only if necessary).
• Lactation Category: Use with caution.
• Pediatric Use: Not recommended for children.
• Geriatric Use: Monitor closely for adverse effects in elderly patients.

Conclusion:

Adalat LA 60 mg Tab is a potent calcium channel blocker used for managing hypertension and angina. Proper monitoring of blood pressure, heart rate, and liver function is essential for optimal treatment outcomes.