Actifed DM Cough Tab 500’s-Potential Overview:

Brand Name: Actifed DM Cough
Generic Name: Triprolidine Hydrochloride + Pseudoephedrine Hydrochloride + Dextromethorphan Hydrobromide
Active Ingredient(s):

• Triprolidine Hydrochloride: Antihistamine
• Pseudoephedrine Hydrochloride: Decongestant
• Dextromethorphan Hydrobromide: Cough suppressant

For the General Public:

Uses:
Actifed DM Cough Tablets are commonly used to relieve:

• Cough caused by minor throat and bronchial irritation.
• Nasal congestion associated with the common cold, hay fever, or other upper respiratory allergies.

How It Works:

• Triprolidine: Blocks histamine H1 receptors, relieving symptoms such as sneezing and runny nose.
• Pseudoephedrine: Shrinks blood vessels in the nasal passages, reducing nasal congestion.
• Dextromethorphan: Suppresses the cough reflex by acting on the cough center in the brain.

Dosage:

• Adults and children over 12 years: 1 tablet every 4-6 hours, not exceeding 4 tablets in 24 hours.
• Always follow the instructions on the packaging or as prescribed by your doctor.

Possible Side Effects:

• Common Side Effects:
  • Drowsiness, dry mouth, dizziness, nausea, headache.
• Serious (Less Common) Side Effects:
  • Fast or irregular heartbeat, hallucinations, or severe allergic reactions.

Important Information:

• Dosage Instruction: Take as directed by a healthcare provider; do not exceed the recommended dose.
• Usage Instruction: Take with or without food.
• General Information:
  • Avoid alcohol and other sedatives as they can increase drowsiness.
  • Do not use if allergic to any ingredients.
  • Consult your doctor if pregnant, breastfeeding, or planning to conceive.
  • Keep out of reach of children.

Drug Interactions:

• Interactions with Other Medications:
  • Avoid MAOIs, beta-blockers, and other CNS depressants.
• Interactions with Food:
  • Avoid alcohol to prevent enhanced sedation.

Regulatory Approval & Manufacturer:
Approved by [regulatory authority], manufactured by [manufacturer].

Antidotes (If Overdose or Misuse):
Overdose symptoms may include restlessness, rapid heartbeat, severe drowsiness, or hallucinations. Seek immediate medical attention.

For Pharmacists:

Medicine Name: Actifed DM Cough
Brand: Actifed DM Cough
Active Ingredient(s):

• Triprolidine Hydrochloride
• Pseudoephedrine Hydrochloride
• Dextromethorphan Hydrobromide

Indications:

• Relief of cough and nasal congestion associated with respiratory tract infections or allergies.

Pharmacodynamics:

• Mechanism of Action:
  • Triprolidine Hydrochloride: Antagonizes histamine H1 receptors to reduce allergic symptoms.
  • Pseudoephedrine Hydrochloride: Activates alpha-adrenergic receptors to reduce nasal swelling.
  • Dextromethorphan Hydrobromide: Suppresses the cough reflex by acting on the medullary cough center.
• Pharmacological Effects:
  • Relieves cough, sneezing, and nasal congestion.
• Receptor Binding:
  • Triprolidine binds to H1 histamine receptors.
  • Pseudoephedrine binds to alpha-adrenergic receptors.
  • Dextromethorphan binds to sigma-1 receptors in the brain.

Pharmacokinetics:

• Absorption: Well absorbed orally, with effects seen within 15-30 minutes.
• Distribution: Distributed throughout body tissues; pseudoephedrine crosses the blood-brain barrier.
• Metabolism:
  • Dextromethorphan metabolized in the liver via CYP2D6.
  • Triprolidine and pseudoephedrine undergo partial hepatic metabolism.
• Elimination: Excreted primarily in urine.
• Half-Life:
  • Triprolidine: ~3-5 hours.
  • Pseudoephedrine: ~5-8 hours.
  • Dextromethorphan: ~2-4 hours.

Dosage and Administration:

• Adults and Children >12 years: 1 tablet every 4-6 hours, maximum of 4 tablets per day.
• Pediatric: Not recommended for children under 12 years.

Contraindications:

• Hypersensitivity to any component.
• Severe hypertension, coronary artery disease, or use of MAOIs within 14 days.

Warnings and Precautions:

• Use cautiously in patients with:
  • Cardiovascular disease, diabetes, hyperthyroidism, or glaucoma.
  • Prostatic hypertrophy or urinary retention.

Drug-Drug Interactions:

• Avoid concurrent use with:
  • MAOIs, beta-blockers, and CNS depressants.

Drug-Food Interactions:

• Alcohol may enhance the sedative effects of the medication.

Adverse Reactions:

• Common: Drowsiness, dry mouth, nausea, and dizziness.
• Serious: Severe allergic reactions, palpitations, or hallucinations.

Therapeutic Effects:

• Quick relief of cough and nasal congestion.

Storage:
Store at 15-25°C, in a cool and dry place away from light.

Packaging:
Pack of 500 tablets.

Clinical Considerations:

• Pregnancy Category: C (Use only if clearly needed).
• Lactation: Use with caution; may pass into breast milk.
• Pediatric: Not recommended for children under 12 years.
• Geriatric: Increased sensitivity to side effects; monitor closely.

Conclusion:

Actifed DM Cough Tab 500’s effectively relieves cough and nasal congestion caused by colds or allergies. Patients should follow prescribed dosages and avoid alcohol. Pharmacists should counsel patients on possible side effects and interactions, especially for those with underlying conditions.