Aclova Tab 400 Mg 10’s-Potential Overview:

Brand Name: Aclova
Generic Name: Aceclofenac
Active Ingredient(s): Aceclofenac 400 mg

For the General Public:

Uses:
Aclova is used to relieve:

• Pain and inflammation associated with osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis.
• Mild to moderate acute pain conditions.

How It Works:
Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) that reduces pain and inflammation by inhibiting cyclooxygenase (COX) enzymes, which are involved in the synthesis of prostaglandins.

Dosage:

• Adults: 1 tablet twice daily, preferably with food.
• Always follow the dosage as prescribed by your doctor.

Possible Side Effects:

• Common Side Effects:
  • Nausea, diarrhea, indigestion, dizziness, abdominal pain.
• Serious (Less Common) Side Effects:
  • Severe gastrointestinal bleeding, allergic reactions, kidney or liver dysfunction.

Important Information:

• Dosage Instruction: Take with food or immediately after meals to reduce gastrointestinal discomfort.
• Usage Instruction: Swallow the tablet with water; do not crush or chew.
• General Information:
  • Avoid alcohol while taking this medication to reduce the risk of stomach irritation.
  • Not recommended for individuals allergic to NSAIDs.
  • Consult a doctor if you are pregnant, breastfeeding, or planning to conceive.
  • Store the medication at room temperature, away from moisture and light.

Drug Interactions:

• Interactions with Other Medications:
  • Avoid concurrent use with other NSAIDs, blood thinners (e.g., warfarin), or corticosteroids.
• Interactions with Food:
  • Taking the tablet with food can reduce the risk of stomach upset. Avoid alcohol.

Regulatory Approval & Manufacturer:
Approved by [regulatory authority], manufactured by [manufacturer].

Antidotes (If Overdose or Misuse):
Symptoms of overdose include severe stomach pain, vomiting, or difficulty breathing. Seek immediate medical attention.

For Pharmacists:

Medicine Name: Aclova
Brand: Aclova
Active Ingredient(s): Aceclofenac 400 mg

Indications:

• Management of pain and inflammation in:
  • Osteoarthritis
  • Rheumatoid arthritis
  • Ankylosing spondylitis

Pharmacodynamics:

• Mechanism of Action:
  Aceclofenac inhibits the activity of cyclooxygenase (COX-1 and COX-2) enzymes, reducing the production of prostaglandins, which mediate pain and inflammation.
• Pharmacological Effects:
  • Anti-inflammatory
  • Analgesic
  • Antipyretic
• Receptor Binding:
  Binds non-selectively to COX-1 and COX-2 enzymes.

Pharmacokinetics:

• Absorption: Rapidly absorbed after oral administration; bioavailability ~60%.
• Distribution: Extensively bound to plasma proteins (~99%).
• Metabolism: Metabolized in the liver to active metabolites.
• Elimination: Primarily excreted via urine (~70%).
• Half-Life: 4-5 hours.

Dosage and Administration:

• Adults: 400 mg per day in divided doses (200 mg twice daily).
• Pediatric: Not recommended for children.
• Special Populations:
  • Use with caution in elderly patients or those with renal or hepatic impairment.

Contraindications:

• Hypersensitivity to aceclofenac or other NSAIDs.
• History of gastrointestinal bleeding or perforation.
• Severe liver or kidney disease.

Warnings and Precautions:

• Use cautiously in patients with:
  • Cardiovascular disease or hypertension.
  • Gastrointestinal disorders (e.g., ulcers, bleeding).
• Monitor liver and kidney function periodically.

Drug-Drug Interactions:

• Increased risk of bleeding with anticoagulants or antiplatelet drugs.
• Reduced effectiveness of diuretics and antihypertensives.
• Risk of toxicity with methotrexate or lithium.

Drug-Food Interactions:

• Food delays absorption but reduces gastrointestinal side effects.
• Avoid alcohol to minimize the risk of gastrointestinal irritation.

Adverse Reactions:

• Common: Nausea, diarrhea, dizziness, headache.
• Serious: GI bleeding, hepatotoxicity, nephrotoxicity.

Therapeutic Effects:

• Effective pain and inflammation relief in arthritis and musculoskeletal conditions.

Storage:
Store at 15-30°C in a dry place away from direct sunlight.

Packaging:
Available in packs of 10 tablets.

Clinical Considerations:

• Pregnancy Category: C (Avoid in the third trimester).
• Lactation: Not recommended; may pass into breast milk.
• Pediatric: Not indicated for children.
• Geriatric: Increased sensitivity; use with caution.

Conclusion:

Aclova Tab 400 Mg 10’s is an effective NSAID for managing pain and inflammation in arthritis and other conditions. Patients should adhere to the prescribed dosage and avoid alcohol. Pharmacists should counsel on potential drug interactions and monitor high-risk patients, such as the elderly and those with gastrointestinal or cardiovascular concerns.