Acemed 100 mg Tab 20’s-Potential Overview:

Brand Name: Acemed
Generic Name: Aceclofenac
Active Ingredient(s): Aceclofenac 100 mg

For the General Public:

Uses:
Acemed is commonly used to:

• Relieve pain and inflammation in conditions like osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis.
• Manage acute musculoskeletal pain and post-operative pain.

How It Works:
Aceclofenac is a nonsteroidal anti-inflammatory drug (NSAID) that works by inhibiting the production of prostaglandins, reducing pain and inflammation.

Dosage:

• Adults: One 100 mg tablet twice daily, taken with or after food.
• Children: Not recommended unless prescribed by a doctor.

Possible Side Effects:

• Common Side Effects: Nausea, vomiting, abdominal pain, dizziness, and diarrhea.
• Serious Side Effects: Gastrointestinal bleeding, liver dysfunction, kidney impairment, and severe allergic reactions.

Important Information:

• Dosage Instruction: Take only as prescribed; do not exceed the recommended dose.
• Usage Instruction: Take with food or milk to reduce the risk of stomach upset.
• General Information:
  • Avoid if allergic to aceclofenac or other NSAIDs.
  • Consult your doctor if you are pregnant, breastfeeding, or taking other medications.
  • Store in a cool, dry place, away from direct sunlight.

Drug Interactions:

• Interactions with Other Medications:
  • Increased bleeding risk with anticoagulants (e.g., warfarin).
  • Reduced efficacy of antihypertensive drugs (e.g., ACE inhibitors).
• Interactions with Food:
  • Alcohol increases the risk of gastrointestinal side effects like bleeding.

Regulatory Approval & Manufacturer:
Approved by [regulatory authority], manufactured by [manufacturer].

Antidotes (If Overdose or Misuse):
Symptoms of overdose include nausea, confusion, and dizziness. Seek immediate medical attention for symptomatic treatment and supportive care.

For Pharmacists:

Medicine Name: Acemed
Brand: Acemed
Active Ingredient(s): Aceclofenac 100 mg

Indications:

• Relief of pain and inflammation associated with osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis.
• Management of acute musculoskeletal pain and post-operative pain.

Pharmacodynamics:

• Mechanism of Action:
  Aceclofenac inhibits cyclooxygenase enzymes (COX-1 and COX-2), reducing prostaglandin synthesis. This decreases inflammation, pain, and fever.
• Pharmacological Effects:
  • Anti-inflammatory
  • Analgesic (pain-relieving)
  • Antipyretic (fever-reducing)
• Receptor Binding:
  Aceclofenac indirectly reduces prostaglandin-mediated responses by blocking their synthesis and does not bind directly to prostaglandin receptors.

Pharmacokinetics:

• Absorption: Rapidly absorbed, with peak plasma concentrations reached within 1.25–3 hours.
• Distribution: High plasma protein binding (~99%).
• Metabolism: Metabolized in the liver to active metabolites, including 4′-hydroxyaceclofenac.
• Elimination: Excreted in urine as metabolites.
• Half-Life: Approximately 4 hours.
• Effect of Food: Food may slightly delay absorption but does not affect overall bioavailability.

Dosage and Administration:

• Adults: 100 mg twice daily, preferably taken with food.
• Pediatric: Not recommended unless specifically prescribed.
• Special Populations:
  • Adjust dosage for elderly patients and those with hepatic or renal impairment.

Contraindications:

• Hypersensitivity to aceclofenac or NSAIDs.
• Active or recurrent peptic ulcers, gastrointestinal bleeding, or severe liver/kidney impairment.
• Third trimester of pregnancy.

Warnings and Precautions:

• Use cautiously in patients with cardiovascular disease, hypertension, or renal impairment.
• Monitor for signs of gastrointestinal bleeding or ulceration.

Drug-Drug Interactions:

• Increased bleeding risk with anticoagulants (e.g., warfarin).
• Reduced antihypertensive effects with ACE inhibitors or diuretics.
• Potential toxicity with methotrexate and lithium.

Drug-Food Interactions:

• Alcohol consumption increases the risk of gastrointestinal irritation and bleeding.

Adverse Reactions:

• Common: Nausea, vomiting, diarrhea, dizziness, and headache.
• Serious: Gastrointestinal bleeding, severe allergic reactions, liver dysfunction, and renal impairment.

Therapeutic Effects:

• Effective in relieving pain and reducing inflammation in musculoskeletal and rheumatic conditions.

Storage:
Store at 15-30°C in a dry place, away from moisture and light.

Packaging:
Available in packs of 20 tablets (100 mg each).

Clinical Considerations:

• Pregnancy Category: C (avoid in the third trimester).
• Lactation: Use cautiously; may pass into breast milk.
• Pediatric Use: Not recommended unless prescribed.
• Geriatric Use: Increased risk of gastrointestinal and renal side effects.

Conclusion:

Acemed 100 mg Tab 20’s is a reliable NSAID for managing pain and inflammation associated with arthritis and other musculoskeletal conditions. Patients should use it as directed and avoid alcohol to minimize gastrointestinal risks. Pharmacists should educate patients about potential interactions and caution those with pre-existing conditions. Proper use ensures effective symptom relief with reduced risks.