Accupril Tab 10 Mg 28’s-Potential Overview:

Brand Name: Accupril
Generic Name: Quinapril
Active Ingredient(s): Quinapril hydrochloride

For the General Public:

Uses:
Accupril 10 mg is commonly used to:

• Treat high blood pressure (hypertension).
• Manage symptoms of heart failure.

How It Works:
Quinapril is an angiotensin-converting enzyme (ACE) inhibitor. It lowers blood pressure by relaxing blood vessels and reducing the workload on the heart.

Dosage:

• Take 10 mg once daily or as prescribed by your doctor.
• May be taken with or without food.

Possible Side Effects:

• Common Side Effects: Dizziness, fatigue, headache, dry cough.
• Serious Side Effects: Swelling of the face, lips, or throat (angioedema), severe abdominal pain, or jaundice (yellowing of the skin or eyes).

Important Information:

• Dosage Instruction: Follow the prescribed dosage; do not increase or skip doses without consulting your doctor.
• Usage Instruction: Swallow the tablet whole with water. Avoid crushing or chewing.
• General Information:
  • Avoid potassium supplements or salt substitutes unless advised by your doctor.
  • Notify your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding.
  • Keep the medication out of reach of children.
  • If you miss a dose, take it as soon as you remember unless it is close to the next scheduled dose.

Drug Interactions:

• With Other Medications: Quinapril may interact with diuretics, NSAIDs, or other blood pressure medications.
• With Food: High-sodium foods may reduce the drug’s effectiveness.

Regulatory Approval & Manufacturer:
Approved by [authority], manufactured by [manufacturer].

Antidotes (If Overdose or Misuse):
Symptoms of overdose include severe hypotension. Seek immediate medical care. Supportive measures such as IV fluids may be required.

For Pharmacists:

Medicine Name: Accupril
Brand: Accupril
Active Ingredient(s): Quinapril hydrochloride

Indications:

• Hypertension.
• Heart failure management.

Pharmacodynamics:

• Mechanism of Action: Quinapril inhibits angiotensin-converting enzyme (ACE), reducing angiotensin II formation. This causes vasodilation, decreased aldosterone secretion, and lowered systemic vascular resistance.
• Pharmacological Effects: Decreases blood pressure and cardiac workload, improves symptoms of heart failure.
• Receptor Binding: Quinapril competitively binds to ACE receptors, preventing angiotensin II-mediated vasoconstriction and aldosterone effects.

Pharmacokinetics:

• Absorption: Well absorbed; peak plasma concentration achieved within 1–2 hours.
• Distribution: Quinaprilat, the active metabolite, shows significant tissue-binding affinity.
• Metabolism: Quinapril is a prodrug, converted to quinaprilat in the liver.
• Elimination: Mainly excreted via urine; impaired in renal dysfunction.
• Half-Life: 2–3 hours for quinapril; prolonged in renal impairment.
• Bioavailability: Approximately 60%.
• Effect of Food: Food may delay absorption slightly but does not reduce overall bioavailability.

Dosage and Administration:

• Adults: Start with 10–20 mg daily. Adjust as needed, up to a maximum of 80 mg per day in divided doses.
• Pediatric Use: Not recommended.
• Special Populations: Adjust dose in patients with renal impairment or the elderly.

Contraindications:

• Hypersensitivity to quinapril or other ACE inhibitors.
• History of angioedema related to ACE inhibitors.
• Use during pregnancy and lactation.

Warnings and Precautions:

• Caution in patients with renal impairment or a history of angioedema.
• Regularly monitor potassium levels to avoid hyperkalemia.
• Advise patients to maintain hydration to prevent hypotension.

Drug-Drug Interactions:

• With Diuretics: May increase the risk of hypotension.
• With Potassium-Sparing Diuretics or Supplements: Risk of hyperkalemia.
• With NSAIDs: Reduced antihypertensive effects.

Drug-Food Interactions:

• Avoid excessive sodium intake, which can counteract the antihypertensive effects.

Adverse Reactions:

• Common: Dizziness, headache, nausea, dry cough.
• Serious: Angioedema, hyperkalemia, renal dysfunction.

Therapeutic Effects:

• Effectively reduces blood pressure.
• Enhances quality of life in patients with heart failure.

Storage:
Store at 15–30°C in a dry place away from direct sunlight.

Packaging:
Available as 10 mg tablets in blister packs containing 28 tablets.

Clinical Considerations:

• Pregnancy Category: D (Contraindicated during pregnancy).
• Lactation: Not recommended; the drug may pass into breast milk.
• Geriatric Use: Start at a lower dose due to the potential for renal impairment.

Conclusion:

Accupril Tab 10 Mg is an effective ACE inhibitor for managing hypertension and heart failure. Patients must adhere to the prescribed dose and report any signs of adverse effects like angioedema or persistent cough. Pharmacists should counsel patients on potential drug and food interactions while monitoring renal function and potassium levels. Proper storage and handling are essential to ensure the medication’s efficacy.